下丘脑-垂体-肾上腺轴参与动物采食调控的研究进展

doi:10.16431/j.cnki.1671-7236.2019.08.011

Abstract

Abstract:

Feeding is the basic physiological process of animal survival, growth and development.Food intake of livestock and poultry directly affects the absorption of nutrients and production performance.In animal production, feeding is affected by many factors, and stress is one of the most important factors.The stress response of animal is mainly regulated by the hypothalamic-pituitary-adrenal (HPA) axis.The hypothalamus, pituitary and adrenal cortex regulate the stress response of the animals by releasing three stress hormones such as corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and glucocorticoid (GC).The regulation of feeding by stress hormones is a very complex process where it can regulates feed intake in both positive and negative way.Specifically, stress hormones may participate in both homeostatic and non-homeostatic pathways to regulate eating behavior.Homeostatic pathways refer to the regulation of food intake by sensing energy status of the body.In this case, CRH and ACTH inhibit feed intake by inhibiting the expression of the appetite peptide in the hypothalamus;GC plays a completely opposite role in the central and peripheral regions.The non-homeostatic pathways refer to the regulation of hedonic eating by modulating the midbrain reward system.It is a hotspot in the study of appetite regulation in recent years.More and more studies have focused on the crosstalk between stress hormone and reward system.In this review, the latest researches on regulation of feeding by stress hormone will be summarized.It will provide some theoretic basis for the development of new techniques on feeding regulation in animal production.

Key words: hypothalamus-pituitary-adrenal axis; stress; feeding

CLC Number:

Q493.99

WU Hanyu, WANG Lina. Research Advances on Effects of Hypothalamic-pituitary-adrenal Axis in Animal Feeding Regulation[J]. China Animal Husbandry & Veterinary Medicine, 2019, 46(8): 2281-2287.

References 62

[1]	RENAUDEAU D,GOURDINE J L,ST-PIERRE N R.A meta-analysis of the effects of high ambient temperature on growth performance of growing-finishing pigs[J]. Journal of Animal Science,2011,89(7):2220-2230.
[2]	钱朝海,李四元,李文,等.仔猪断奶应激的探析及其防治措施[J].中国畜牧兽医,2006,33(9):58-60. QIAN C H,LI S Y,LI W,et al.Researching piglets ablactation stress syndrome produce reasons and prevention[J]. China Animal Husbandry & Veterinary Medicine,2006,33(9):58-60.(in Chinese)
[3]	GEHLERT D R.Role of hypothalamic neuropeptide Y in feeding and obesity[J]. Neuropeptides,1999,33(5):329-338.
[4]	VALASSI E,SCACCHI M,CAVAGNINI F.Neuroendocrine control of food intake[J]. Nutrition,Metabolism and Cardiovascular Diseases,2008,18(2):158-168.
[5]	SMITH P M,FERGUSON A V.Neurophysiology of hunger and satiety[J]. Developmental Disabilities Research Reviews,2008,14(2):96-104.
[6]	SCHWARTZ M W,WOODS S C,PORTE D J R,et al.Central nervous system control of food intake[J]. Nature,2000,404(6778):661-671.
[7]	KOOB G F,ZORRILLA E P.Neurobiological mechanisms of addiction:Focus on corticotropin-releasing factor[J]. Current Opinion in Investigational Drugs,2010,11(1):63-71.
[8]	SPANAGEL R,NOORI H R,HEILIG M.Stress and alcohol interactions:Animal studies and clinical significance[J]. Trends in Neurosciences,2014,37(4):219-227.
[9]	GOLD P W,CHROUSOS G P.Organization of the stress system and its dysregulation in melancholic and atypical depression:High vs low CRH/NE states[J]. Molecular Psychiatry,2002,7(3):254-275.
[10]	KELLY E A,FUDGE J L.The neuroanatomic complexity of the CRF and DA systems and their interface:What we still don't know[J]. Neuroscience and Biobehavioral Reviews,2018,90:247-259.
[11]	NIEUWENHUIZEN A G,RUTTERS F.The hypothalamic-pituitary-adrenal axis in the regulation of energy balance[J]. Physiology & Behavior,2008,94(2):169-177.
[12]	BAIGENT S M.Peripheral corticotropin-releasing hormone and urocortin in the control of the immune response[J]. Peptides,2001,22(5):809-820.
[13]	廖丽萍.高脂饮食对大鼠下丘脑前增食欲素原及CRH表达的影响[J].福建医药杂志,2010,32(1):86-87. LIAO L P.Effect of high-fat diet on the expression of orexin and CRH in rat hypothalamus[J]. Fujian Medical Journal,2010,32(1):86-87.(in Chinese)
[14]	CICCOCIOPPO R,FEDELI A,ECONOMIDOU D,et al.The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/orphanin FQ[J]. Journal of Neuroscience,2003,23(28):9445-9451.
[15]	SUWANAPAPORN P,CHAIYABUTR N,THAMMACHAROEN S.A low degree of high ambient temperature decreased food intake and activated median preoptic and arcuate nuclei[J]. Physiology & Behavior,2017,181:16-22.
[16]	HEINRICHS S C,MENZAGHI F,PICH E M,et al.Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y[J]. Brain Research,1993,611(1):18-24.
[17]	CURRIE P J.Integration of hypothalamic feeding and metabolic signals:Focus on neuropeptide Y[J]. Appetite,2003,41(3):335-337.
[18]	MO C,CAI G,HUANG L,et al.Corticotropin-releasing hormone (CRH) stimulates cocaine-and amphetamine-regulated transcript gene (CART1) expression through CRH type 1 receptor (CRHR1) in chicken anterior pituitary[J]. Molecular and Cellular Endocrinology,2015,417:166-177.
[19]	CRAMER T,KISLIOUK T,YESHURUN S,et al.The balance between stress resilience and vulnerability is regulated by corticotropin-releasing hormone during the critical postnatal period for sensory development[J]. Developmental Neurobiology,2015,75(8):842-853.
[20]	WENINGER S C,MUGLIA L J,JACOBSON L,et al.CRH-deficient mice have a normal anorectic response to chronic stress[J]. Regulatory Peptides,1999,84(1-3):69-74.
[21]	RICHARD D,LIN Q,TIMOFEEVA E.The corticotropin-releasing factor family of peptides and CRF receptors:Their roles in the regulation of energy balance[J]. European Journal of Pharmacology,2002,440(2-3):189-197.
[22]	TANAKA C,ASAKAWA A,USHIKAI M,et al.Comparison of the anorexigenic activity of CRF family peptides[J]. Biochemical and Biophysical Research Communications,2009,390(3):887-891.
[23]	YAKABI K,NOGUCHI M,OHNO S,et al.Urocortin 1 reduces food intake and ghrelin secretion via CRF(2) receptors[J]. American Journal of Physiology Endocrinology and Metabolism,2011,301(1):E72-E82.
[24]	WANG L,STENGEL A,GOEBEL S M,et al.Intravenous injection of urocortin 1 induces a CRF2 mediated increase in circulating ghrelin and glucose levels through distinct mechanisms in rats[J]. Peptides,2013,39:164-170.
[25]	KOOB G F.Neurobiological substrates for the dark side of compulsivity in addiction[J]. Neuropharmacology,2009,56(Suppl 1):18-31.
[26]	PUCCI M,MICIONI DI BONAVENTURA M V,GIUSEPPONI M E,et al.Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption[J]. Addiction Biology,2016,21(6):1168-1185.
[27]	LEONARD M Z,DEBOLD J F,MICZEK K A.Escalated cocaine "binges" in rats:Enduring effects of social defeat stress or intra-VTA CRF[J]. Psychopharmacology,2017,234(18):2823-2836.
[28]	GRIEDER T E,HERMAN M A,CONTET C,et al.VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation[J]. Nature Neuroscience,2014,17(12):1751-1758.
[29]	CONTARINO A,KITCHENER P,VALL E M,et al.CRF1 receptor-deficiency increases cocaine reward[J]. Neuropharmacology,2017,117:41.
[30]	RINKER J A,MARSHALL S A,MAZZONE C M,et al.Extended amygdala to ventral tegmental area corticotropin-releasing factor circuit controls binge ethanol intake[J]. Biological Psychiatry,2017,81(11):930-940.
[31]	OSTROUMOV A,THOMAS A M,KIMMEY B A,et al.Stress increases ethanol self-administration via a shift toward excitatory GABA signaling in the ventral tegmental area[J]. Neuron,2016,92(2):493-504.
[32]	MARTIN J,TIMOFEEVA E.Intermittent access to sucrose increases sucrose-licking activity and attenuates restraint stress-induced activation of the lateral septum[J]. American Journal of Physiology Regulatory Integrative and Comparative Physiology,2010,298(5):R1383-R1398.
[33]	TRYON M S,STANHOPE K L,EPEL E S,et al.Excessive sugar consumption may be a difficult habit to break:A view from the brain and body[J]. Journal of Clinical Endocrinology and Metabolism,2015,100(6):2239-2247.
[34]	ULRICH-LAI Y M,CHRISTIANSEN A M,OSTRANDER M M,et al.Pleasurable behaviors reduce stress via brain reward pathways[J]. Proceedings of the National Academy of Sciences of the United States of America,2010,107(47):20529-20534.
[35]	FOSTER M T,WARNE J P,GINSBERG A B,et al.Palatable foods,stress,and energy stores sculpt corticotropin-releasing factor,adrenocorticotropin,and corticosterone concentrations after restraint[J]. Endocrinology,2009,150(5):2325-2333.
[36]	ULRICH-LAI Y M,OSTRANDER M M,THOMAS I M,et al.Daily limited access to sweetened drink attenuates hypothalamic-pituitary-adrenocortical axis stress responses[J]. Endocrinology,2007,148(4):1823-1834.
[37]	WANAT M J,HOPF F W,STUBER G D,et al.Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih[J]. Journal of Physiology,2008,586(8):2157-2170.
[38]	LEMOS J C,WANAT M J,SMITH J S,et al.Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive[J]. Nature,2012,490(7420):402-406.
[39]	FETISSOV S O,HALLMAN J,ORELAND L,et al.Autoantibodies against alpha-MSH,ACTH,and LHRH in anorexia and bulimia nervosa patients[J]. Proceedings of the National Academy of Sciences of the United States of America,2002,99(26):17155-17160.
[40]	KRUDE H,BIEBERMANN H,LUCK W,et al.Severe early-onset obesity,adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans[J]. Nature Genetics,1998,19(2):155-157.
[41]	GANTZ I,KONDA Y,TASHIRO T,et al.Molecular cloning of a novel melanocortin receptor[J]. Journal of Biological Chemistry,1993,268(11):8246-8250.
[42]	AL-BARAZANJI K A,MILLER J E,RICE S Q,et al.C-terminal fragments of ACTH stimulate feeding in fasted rats[J]. Hormone and Metabolic Research,2001,33(8):480-485.
[43]	SCHULZ C,PAULUS K,LOBMANN R,et al.Endogenous ACTH,not only alpha-melanocyte-stimulating hormone,reduces food intake mediated by hypothalamic mechanisms[J]. American Journal of Physiology Endocrinology and Metabolism,2010,298(2):E237-E244.
[44]	SAHIN K,KUCUK O.A simple way to reduce heat stress in laying hens as judged by egg laying,body weight gain and biochemical parameters[J]. Acta Veterinaria Hungarica,2001,49(4):421-430.
[45]	MANETTI L,CAVAGNINI F,MARTINO E,et al.Effects of cocaine on the hypothalamic-pituitary-adrenal axis[J]. Journal of Endocrinological Investigation,2014,37(8):701-708.
[46]	刘磊.糖皮质激素在应激家禽食欲调控中的作用机制[D].泰安:山东农业大学,2014. LIU L.Mechanism of glucocorticoids regulating appetite in stressed poultry[D].Tai'an:Shandong Agricultural University,2014.(in Chinese)
[47]	SAVONTAUS E,CONWELL I M,WARDLAW S L.Effects of adrenalectomy on AGRP,POMC,NPY and CART gene expression in the basal hypothalamus of fed and fasted rats[J]. Brain Research,2002,958(1):130-138.
[48]	KONNO J,YOSHIDA S,INA A,et al.Upregulated expression of neuropeptide Y in hypothalamic-pituitary system of rats by chronic dexamethasone administration[J]. Neuroscience Research,2008,60(3):259-265.
[49]	SHIMIZU H,ARIMA H,WATANABE M,et al.Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats[J]. Endocrinology,2008,149(9):4544-4553.
[50]	KRISTENSSSON E,SUNDQVIST M,ASTIN M,et al.Acute psychological stress raises plasma ghrelin in the rat[J]. Regulatory Peptides,2006,134(2-3):114-117.
[51]	LUTTER M,SAKATA I,OSBORNE-LAWRENCE S,et al.The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress[J]. Nature Neuroscience,2008,11(7):752-753.
[52]	OCHI M,TOMINAGA K,TANAKA F,et al.Effect of chronic stress on gastric emptying and plasma ghrelin levels in rats[J]. Life Sciences,2008,82(15-16):862-868.
[53]	BALSEVICH G,PETRIE G N,HILL M N.Endocannabinoids:Effectors of glucocorticoid signaling[J]. Frontiers in Neuroendocrinology,2017,47:86-108.
[54]	BARROT M,MARINELLI M,ABROUS D N,et al.The dopaminergic hyper-responsiveness of the shell of the nucleus accumbens is hormone-dependent[J]. European Journal of Neuroscience,2000,12(3):973-979.
[55]	NAISH K R,LALIBERTE M,MACKILLOP J,et al.Systematic review of the effects of acute stress in binge eating disorder[J]. European Journal of Neuroscience,2018,Epub Ahead of Print.
[56]	SOMINSKY L,SPENCER S J.Eating behavior and stress:A pathway to obesity[J]. Frontiers in Psychology,2014,5:434.
[57]	DALLMAN M F,PECORARO N C,LA FLEUR S E.Chronic stress and comfort foods:Self-medication and abdominal obesity[J]. Brain,Behavior,and Immunity,2005,19(4):275-280.
[58]	MAKINO S,SCHULKIN J,SMITH M A,et al.Regulation of corticotropin-releasing hormone receptor messenger ribonucleic acid in the rat brain and pituitary by glucocorticoids and stress[J]. Endocrinology,1995,136(10):4517-4525.
[59]	JEQUIER E.Leptin signaling,adiposity,and energy balance[J]. Annals of the New York Academy of Sciences,2002,967:379-388.
[60]	UCHOA E T,SILVA L E,DE CASTRO M,et al.Glucocorticoids are required for meal-induced changes in the expression of hypothalamic neuropeptides[J]. Neuropeptides,2012,46(3):119-124.
[61]	STRACK A M,SEBASTIAN R J,SCHWARTZ M W,et al.Glucocorticoids and insulin:Reciprocal signals for energy balance[J]. American Journal of Physiology,1995,268(1-2):142-149.
[62]	MARINELLI M,PIAZZA P V.Interaction between glucocorticoid hormones,stress and psychostimulant drugs[J]. European Journal of Neuroscience,2002,16(3):387-394.

Research Advances on Effects of Hypothalamic-pituitary-adrenal Axis in Animal Feeding Regulation

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 62

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	PING Yuyu, HUANG Xuan, CAI Qingqing, WANG Qiangzhou, WANG Jiaxing, BAI Hao, CHEN Shihao, CHANG Guobin. Prediction of Biological Function of gga-miR-1574-5p and Verification of Its Targeting Relationship with G3BP2 Gene [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 2981-2991.
[2]	WANG Ru, WANG Jiahao, OU Jingyu, TANG Wenhui, CHENG Xiao, WANG Qiangjun, CHEN Jiahong, ZHANG Zijun, REN Chunhuan. Effect of Antioxidants on Freezing Effect of Semen in Ruminants [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3242-3255.
[3]	LYU Xueze, REN Haiyuan, WANG Liang, XIE Shiyong, YANG Weifang, LIU Jun, WU Shugeng, WU Dimei, LIU Yanhan. Effects of Overfeeding Time on Growth Performance,Slaughter Performance, Nutritional Quality and Intestinal Morphology of Pekin Ducks [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2582-2591.
[4]	YU Miao, LI Yanjiao, ZHAO Yanling, CHAO Zhe, WANG Feng, LI Menghan, JIANG Zhiqiang, ZHANG Ting, XUE Xinyu, REN Zili, SUN Ruiping. Effects of Weaning Stress on Intestinal Morphology, Antioxidant Capacity and Nrf2 Signaling Pathway of Wuzhishan Piglets [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2045-2055.
[5]	SUN Yuli, JIAO Ning, QU Yanghua, ZHANG Lei, ZHANG Xiaolin. Advance on the Feeding Value of Black Soldier Fly Larvae and Its Application in Pig Production [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2066-2077.
[6]	GAO Zihao, LI Jia, ZHANG Linhui, ZHANG Ci, LIU Bingnan, LI Junjie, XIA Wei. Research Progress on the Regulatory Mechanisms of Mitochondria in the Maturation of Domestic Animal Oocytes [J]. China Animal Husbandry and Veterinary Medicine, 2025, 52(5): 2232-2242.
[7]	MIAO Xinyuan, XU Qingyu, XIA Sugan, LIN Tianjin, CAI Guodong, ZOU Hui, GU Jianhong, YUAN Yan, LIU Zongping, BIAN Jianchun. Mechanism of Action of Testosterone Synthesis Disorder in Male Mice Induced by Polystyrene Nanoplastics [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1488-1498.
[8]	LI Yajuan, SONG Kelin, LI Jie, ZHANG Yali, LIANG Yuhao, LI Yao, GUN Shuangbao, GAO Xiaoli. Research Progress on the Effects of Cold Stress on Animal Energy Metabolism and Its Molecular Regulation [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1616-1626.
[9]	HONG Jiajun, XIAO Jinhua, ZHANG Zheng, YANG Yuting, FANG Chun, HAN Xu. Effect of sod Gene Deletion on the Anti-oxidative Stress in Listeria monocytogenes 10403S [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1776-1783.
[10]	TAO Siming, LIANG Hui, YAN Chang, LONG Runze, XU Ruiqing, LI Zixu, WU Yingjie, LIU Ning, QIN Yinghe. Effects of Dietary Chlorogenic Acid on Reproductive Performance of Female Rabbits and Growth of Suckling Rabbits [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 1080-1088.
[11]	AN Zhaoxiang, XUN Wenjuan, ZHOU Hanlin, SHI Liguang. Effects of Heat Stress on Semen Antioxidant Capacity and Seminal Plasma Metabolomics in Hainan Black Goats [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 1191-1201.
[12]	LI Xi, LIU Jianying, FANG Lihua, YIN Yulong, TANG Yulong. Functional Study on SodA,TrxA and TrxC Genes of Streptococcus suis Type 2 [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 1428-1436.
[13]	ZHONG Ming, GENG Longjun, CUI Lianhua, XU Ziyan, YAN Changguo, FENG Jian, CAI Hongfan, ZHANG Xu. Effects of Curcumin on Growth Performance, Apparent Digestibility of Feed Nutrients and Blood Indexes of Yanbian Yellow Breeding Cattle Under Heat Stress [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 655-667.
[14]	LU Rui, SHENG Hui, GUO Yanyan, ZHANG Yuxin, YAO Dawei, GUO Xiaofei, RUAN Weibin, ZHANG Xiaosheng. Research Progress on Immune Stress of LPS [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 946-958.
[15]	TIAN Huihui, WANG Bingxin, ZHU Zhaoyan, YU Yange, DING Mengxia, TIAN Yadong, JIANG Ruirui, SUN Guirong, HAN Ruili, KANG Xiangtao, YAN Fengbin, GUO Yujie. Cloning,Bioinformatics Analysis of HSPA8 Gene and Its Expression Pattern in Thymus in Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(1): 39-51.