ROS介导的氧化应激与自噬

doi:10.16431/j.cnki.1671-7236.2018.03.013

Abstract

Abstract:

Autophagy is unique to eukaryotic cells that the intracellular material composition is degraded by lysosomal.Living organisms remove cells waste and rebulid structure through the autophagy process so as to maintain the protein metabolism balance and stable environment in the cell.Oxidative is the imbalance between oxidation and antioxidation,which tends to oxidation,resulting in inflammatory infiltrating of neutrophils,secretion of added protease.Subsequently,it will produce a large number of reactive oxygen species (ROS),and it directly involves in the regulation of cell survival and death.A large number of studies have shown that ROS produced in oxidative stress is an important regulator of autophagy in many conditions,and it can induce autophagy.In addition,autophagy can protect cells from damage caused by oxidative stress through different signaling pathways.ROS is the important regulatory factor of autophagy in various conditions.In this paper,the authors will focus on the process of autophagy,the mechanism how the oxidative induces autophagy,such as regulating mTOR,MAPK signaling path,and ways to relieve the oxidative stress though the autophagy,which including mTOR signaling path,PI3K mediated signaling path and regulating p53,hope to provide a theoretical basis for regulating autophagy to alleviate oxidative stress in livestock production.

Key words: oxidative stress; autuophagy; ROS

CLC Number:

Q255

GAO Ting, WANG Zixu, CHEN Zhuming, CAO Jing, DONG Yulan, DONG Yanjun, CHEN Yaoxing. Oxidative Stress and Autophagy Mediated by Reactive Oxygen Species[J]. China Animal Husbandry & Veterinary Medicine, 2018, 45(3): 656-662.

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Oxidative Stress and Autophagy Mediated by Reactive Oxygen Species

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