Abstract: The experiment was conducted to study the effect of colostrum powder and mature milk powder of buffalo on small intestinal tissue morphology development of newborn piglet.Newborn piglets within 72 h in treatments group were fed with buffalo colostrum powder （SCR group），buffalo mature milk powder （SC group） and glucose saline （PY group）， respectively. 0-day-old newborn piglets as control （XD group）.The results showed that intestinal villi of newborn piglets were densely，stout，arranged neatly， the thickness of muscular layer and membranaepropria were increased after taking buffalo colostrum powder. Compared with XD group，villus height，villus width，as well as membranaepropria thickness of duodenum，villus width and muscular layer thickness of jejunum，also and villus height of ileum were extremely significantly increased in SCR group （P＜0.01）.The villus width of duodenum, villus width and muscular layer thickness of jejunum in SCR group were extremely significantly increased than that in PY group （P＜0.01）.Buffalo mature milk powder caused damage to newborn piglets’ intestinal mucosal，including epithelial sheded，muscle layer thinned，membranaepropria naked and intestinal villi collapsed. Compared with XD group，the muscular layer thickness of duodenum,villus height, villus width, muscular layer thickness and membranaepropria thickness of jejunum, villus width and membranaepropria thickness of ileum in SC group were reduced，but there were no significant differences among them （P＞0.05）.However，the muscular layer thickness of jejunum in SC group was significantly decreased than that in PY group （P＜0.05）. In summary，the development of newborn piglets’ intestinal was promoted by feeding with buffalo colostrum powder. The biggest influence on jejunum，followed by duodenum，ileum. There was no effect on protecting intestinal mucosa and promoting its development by buffalo mature milk powder.The value of buffalo mature milk powder was less than glucose saline for development of newborn piglets within 72 h.

Key words: colostrum powder; mature milk powder; newborn piglets; small intestinal; tissue morphology