马运动代谢组及其相关通路研究进展

doi:10.16431/j.cnki.1671-7236.2025.11.004

Abstract

Abstract: With the continuous development of the equine industry,the research on the athletic capabilities of horses has increasingly drawn attention.As an emerging research methodology,metabolomics technologies offer a novel tool for in-depth exploration of the metabolic alterations in horses during exercise.The metabolomics technologies mainly encompass nuclear magnetic resonance (NMR),gas chromatography-mass spectrometry (GC-MS),liquid chromatography-mass spectrometry (LC-MS),etc.,which have been extensively applied in horse sports-related research,covering multiple fields such as sports traits,exercise physiology,and sports-related diseases,which include revealing the dynamic adaptation mechanism of energy metabolism in sports types such as horse speed and endurance,studying the metabolic mechanism of improving the exercise performance of horses through training,identifying the characteristic metabolites of horse sports diseases and providing targets for diagnosis and treatment,and exploring the metabolic mechanism of nutritional intervention and antioxidant strategies on the exercise capacity and body recovery of horses.In the review,the authors systematically introduce the basic concepts and research methods of metabolomics,and focuse on the research results of horse exercise-related metabolomics.At the same time,the metabolic pathways of carbohydrates,proteins and amino acids,and lipids closely related to horse exercise,as well as their dynamic adaptive mechanisms during exercise are summarized.The integration of metabolomics and multi-omics is expected to lead to significant breakthroughs in horse sports-related research.

Key words: horse; exercise; metabolomics; metabolic pathway

CLC Number:

S821

QIAN Shiyu, YAO Ruyu, ZHANG Hetong, XING Wenhui, WU Jiahui, LI Yuanyuan, ZHAO Chunjiang. Advances in Equine Exercise Metabolome and Its Associated Metabolic Pathways[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(11): 5053-5062.

References

[1] 韩国才.传统马业与现代马业[J].中国畜牧杂志,2004,40(12):33-35.HAN G C.Traditional horse industry and modern horse industry[J].Chinese Journal of Animal Science,2004,40(12):33-35.(in Chinese)
[2] KLEIN D J,ANTHONY T G,MCKEEVER K H.Metabolomics in equine sport and exercise[J].Journal of Animal Physiology and Animal Nutrition,2021,105(1):140-148.
[3] OLIVER S G.From gene to screen with yeast[J]. Current Opinion in Genetics & Development,1997,7(3):405-409.
[4] 许国旺,路鑫,杨胜利.代谢组学研究进展[J].中国医学科学院学报,2007,29(6):701-711.XU G W,LU X,YANG S L.Recent advances in metabonomics[J].Acta Academiae Medicinae Sinicae,2007,29(6):701-711.(in Chinese)
[5] 刘瑞,金龙,李明洲.代谢组学在农业动物中的研究与应用[J].中国畜牧杂志,2018,54(6):1-5.LIU R,JIN L,LI M Z.Research and application of metabolomics in agricultural animals[J].Chinese Journal of Animal Science,2018,54(6):1-5.(in Chinese)
[6] 葛宇,吐尼亚孜吾斯曼,陈余,等.代谢组学在畜禽中的研究进展[J].中国畜牧杂志,2021,57(12):42-46.GE Y,TUNIAZI W,CHEN Y,et al.Research progress of metabolomics in livestock and poultry[J].Chinese Journal of Animal Science,2021,57(12):42-46.(in Chinese)
[7] BAHARUM S N,AZIZAN K A.Metabolomics in systems biology[J]. Advances in Experimental Medicine and Biology,2018,1102:51-68.
[8] 金森.代谢组学在畜禽遗传育种中的应用分析[J].中国畜禽种业,2021,17(10):30-31.JIN S.Application analysis of metabolomics in genetic breeding of livestock and poultry[J].The Chinese Livestock and Poultry Breeding,2021,17(10):30-31.(in Chinese)
[9] VAN DEN HOVEN R.Equine exercise physiology—Transforming laboratory studies into practical concepts[J]. Pferdeheilkunde,2006,22(5):525-530.
[10] PAKULA P D,HALAMA A,AL-DOUS E K,et al.Characterization of exercise-induced hemolysis in endurance horses[J].Frontiers in Veterinary Science,2023,10:1115776.
[11] 王建文,姚新奎,曾亚琦,等.不同比赛途程伊犁马赛后血浆代谢组分析[J].动物营养学报,2023,35(6):3832-3842.WANG J W,YAO X K,ZENG Y Q,et al.Plasma metabolomics analysis of Yili horses at different race distances after racing[J]. Chinese Journal of Animal Nutrition,2023,35(6):3832-3842.(in Chinese)
[12] 张仕琦,李晓斌,张文杰,等.补喂L-精氨酸或N-氨甲酰谷氨酸对伊犁马3600 m速度赛赛前赛后血浆中代谢物的影响[J].动物营养学报,2019,31(12):5613-5624.ZHANG S Q,LI X B,ZHANG W J,et al.Effects of supplemented with L-arginine or N-carbamylglutamate on plasma metabolites before and after 3600 m speed race of Yili horses[J].Chinese Journal of Animal Nutrition,2019,31(12):5613-5624.(in Chinese)
[13] 蔺相,文立,张健,等.耐力马心率变异和血气指标与耐力运动能力的关联研究[J].武汉商学院学报,2015,29(6):33-36.LIN X,WEN L,ZHANG J,et al.Study of correlation between heart rate variability & blood gas indexes and endurance performance of stamina horses[J].Journal of Wuhan Commercial Service College,2015,29(6):33-36.(in Chinese)
[14] 姚茹玉,周梦晗,王心雨,等.哺乳动物耐力的遗传基础及研究进展[J].中国畜牧杂志,2025,61(1):46-52.YAO R Y,ZHOU M H,WANG X Y,et al.The genetic basis and research progress of endurance in mammals[J].Chinese Journal of Animal Science,2025,61(1):46-52.(in Chinese)
[15] 魏睿元,赵一萍,白东义,等.蒙古马不同耐力运动水平的血浆代谢组特征研究[J].畜牧兽医学报,2022,53(5):1442-1454.WEI R Y,ZHAO Y P,BAI D Y,et al.Plasma metabolomics features of Mongolian horses with different endurance exercise levels[J].Acta Veterinaria et Zootechnica Sinica,2022,53(5):1442-1454.(in Chinese)
[16] 魏睿元,依波勒图,韩海格,等.蒙古马与杂交马耐力运动前后的血浆代谢组学研究[J].农业生物技术学报,2022,30(11):2141-2151.WEI R Y,YI B,HAN H G,et al.Study on plasma metabolomics of Mongolian horses (Equus caballus) and hybrid horses before and after endurance exercise[J].Journal of Agricultural Biotechnology,2022,30(11):2141-2151.(in Chinese)
[17] TAKAHASHI K,MUKAI K,EBISUDA Y,et al.Effects of pacing strategy on metabolic responses to 2-min intense exercise in Thoroughbred horses[J]. Scientific Reports,2024,14(1):18352.
[18] HALAMA A,OLIVEIRA J M,FILHO S A,et al.Metabolic predictors of equine performance in endurance racing[J].Metabolites,2021,11(2):82.
[19] RIVERO J L L,HILL E W.Skeletal muscle adaptations and muscle genomics of performance horses[J].The Veterinary Journal,2016,209:5-13.
[20] RIVERO J L,GALISTEO A M,AGÜERA E,et al.Skeletal muscle histochemistry in male and female Andalusian and Arabian horses of different ages[J].Research in Veterinary Science,1993,54(2):160-169.
[21] VALBERG S J.Muscle conditions affecting sport horses[J].The Veterinary Clinics of North America.Equine Practice,2018,34(2):253-276.
[22] OHMURA H,MUKAI K,TAKAHASHI Y,et al.Metabolomic analysis of skeletal muscle before and after strenuous exercise to fatigue[J].Scientific Reports,2021,11(1):11261.
[23] 敖乳嘎.训练对蒙古马肌肉发育相关基因MyoG的表达量影响研究[D].呼和浩特：内蒙古农业大学,2016.AO R G.Research of the influence on exercise to the expression of muscle development related gene MyoG in Mongolian horses[D].Hohhot:Inner Mongolia Agricultural University,2016.(in Chinese)
[24] KLEIN D J,MCKEEVER K H,MIREK E T,et al.Metabolomic response of equine skeletal muscle to acute fatiguing exercise and training[J]. Frontiers in Physiology,2020,11:110.
[25] 孙远方,马勇,王建文,等.速度型伊犁马短途比赛前后血浆代谢组学研究[J].动物营养学报,2024,36(4):2561-2571.SUN Y F,MA Y,WANG J W,et al.Study on plasma metabolomics before and after short distance race of speed Yili horses[J].Chinese Journal of Animal Nutrition,2024,36(4):2561-2571.(in Chinese)
[26] RIGANAS C S,PAPADOPOULOU Z,PSICHAS N,et al.The rate of lactate removal after maximal exercise:The effect of intensity during active recovery[J].The Journal of Sports Medicine and Physical Fitness,2015,55(10):1058-1063.
[27] 张保金,欧艺驰,陈武山.饲料中添加植物油对纯血马运动性能、养分表观消化率及血浆代谢指标的影响[J].中国饲料,2020,17:67-70.ZHANG B J,OU Y C,CHEN W S.Effects of vegetable oil added to feed on the performance,apparent digestibility of nutrients and plasma metabolism of thoroughbred horse[J].Chinese Feed, 2020,17:67-70.(in Chinese)
[28] 曹莉萍,臧长江,徐向君,等.日粮中添加氨基酸对焉耆马运动性能、血浆抗氧化能力及代谢指标的影响[J].中国畜牧兽医,2015,42(4):896-902.CAO L P,ZANG C J,XU X J,et al.Effects of supplemental amino acids on the performance,plasma antioxidant capacity and other metabolic index of Yanqi horse[J].China Animal Husbandry & Veterinary Medicine,2015,42(4):896-902.(in Chinese)
[29] 周琛,李海英,臧长江,等.添加硫辛酸对焉耆马运动性能、血浆抗氧化能力及代谢指标的影响[J].中国畜牧兽医,2015,42(3):575-582.ZHOU C,LI H Y,ZANG C J,et al.Effects of supplemental lipoic acid on the sport performance,plasma antioxidant capacity and other metabolic index of Yanqi horse[J].China Animal Husbandry & Veterinary Medicine,2015,42(3):575-582.(in Chinese)
[30] 李海英,周琛,臧长江,等.添加维生素E对焉耆马运动性能、血浆抗氧化能力及代谢指标的影响[J].中国饲料,2015,2:23-26.LI H Y,ZHOU C,ZANG C J,et al.Effects of supplemental vitamin E on the sport performance,plasma antioxidant capacity and metabolie index of Yanqi horse[J].China Feed,2015,2:23-26.(in Chinese)
[31] 李海英,曹莉萍,臧长江,等.添加油脂对焉耆马运动性能、血浆抗氧化能力及代谢指标的影响[J].中国畜牧兽医,2015,42(5):1123-1129.LI H Y,CAO L P,ZANG C J,et al.Effects of supplemental oil on the sport performance,plasma antioxidant capacity and other metabolic index of Yanqi horses[J].China Animal Husbandry & Veterinary Medicine,2015,42(5):1123-1129.(in Chinese)
[32] WICKENS C,BROOKS S A.Genetics of equine behavioral traits[J]. The Veterinary Clinics of North America. Equine Practice,2020,36(2):411-424.
[33] LUCK M M,LE MOYEC L,BARREY E,et al.Energetics of endurance exercise in young horses determined by nuclear magnetic resonance metabolomics[J].Frontiers in Physiology,2015,6:198.
[34] 李鹏程,曾亚琦,王建文,等.基于代谢组学探究调教训练对速步型伊犁马血浆代谢物的影响[J].动物营养学报,2024,36(2):1226-1235.LI P C,ZENG Y Q,WANG J W,et al.To explore influences of breaking and training on plasma metabolites of trot-type Yili horses based on metabolomics[J]. Chinese Journal of Animal Nutrition,2024,36(2):1226-1235.(in Chinese)
[35] TAKAHASHI K,MUKAI K,TAKAHASHI Y,et al.Metabolomic responses to high-intensity interval exercise in equine skeletal muscle:Effects of rest interval duration[J].The Journal of Experimental Biology,2024,227(4):jeb246896.
[36] KITAOKA Y,MUKAI K,AIDA H,et al.Effects of high-intensity training on lipid metabolism in Thoroughbreds[J]. American Journal of Veterinary Research,2012,73(11):1813-1818.
[37] EIVERS S S,MCGIVNEY B A,GU J,et al.PGC-1α encoded by the PPARGC1A gene regulates oxidative energy metabolism in equine skeletal muscle during exercise[J].Animal Genetics,2012,43(2):153-162.
[38] LE MOYEC L,ROBERT C,TRIBA M N,et al.A first step toward unraveling the energy metabolism in endurance horses:Comparison of plasma nuclear magnetic resonance metabolomic profiles before and after different endurance race distances[J].Frontiers in Molecular Biosciences,2019,6:645.
[39] WANG T,ZENG Y,MA C,et al.Plasma non-targeted metabolomics analysis of Yili horses raced on tracks with different surface hardness[J].Journal of Equine Veterinary Science,2023,121:104197.
[40] ANDERSON J R,PHELAN M M,CAAMAÑO-GUTIÉRREZ E,et al.Metabolomic and proteomic stratification of equine osteoarthritis[J/OL].Equine Veterinary Journal,2025.Doi:10.1111/evj.14490.
[41] MCKENZIE E C,EYRICH L V,PAYTON M E,et al.Clinical,histopathological and metabolic responses following exercise in Arabian horses with a history of exertional rhabdomyolysis[J]. The Veterinary Journal，2016,216:196-201.
[42] WOUTERS C P,TOQUET M P,RENAUD B,et al.Metabolomic signatures discriminate horses with clinical signs of atypical myopathy from healthy co-grazing horses[J].Journal of Proteome Research,2021,20(10):4681-4692.
[43] LI Y,XIAO W,LUO W,et al.Alterations of amino acid metabolism in osteoarthritis:Its implications for nutrition and health[J].Amino Acids,2016,48(4):907-914.
[44] BUJAK R,STRUCK-LEWICKA W,MARKUSZEWSKI M J,et al.Metabolomics for laboratory diagnostics[J].Journal of Pharmaceutical and Biomedical Analysis,2015,113:108-120.
[45] VIGH-LARSEN J F,ØRTENBLAD N,SPRIET L L,et al.Muscle glycogen metabolism and high-intensity exercise performance:A narrative review[J].Sports Medicine,2021,51(9):1855-1874.
[46] DASHTY M.A quick look at biochemistry:carbohydrate metabolism[J].Clinical Biochemistry,2013,46(15):1339-1352.
[47] ADEVA-ANDANY M,LÓPEZ-OJÉN M,FUNCASTA-CALDERÓN R,et al.Comprehensive review on lactate metabolism in human health[J].Mitochondrion,2014,17:76-100.
[48] KATZ J,TAYEK J A.Recycling of glucose and determination of the cori cycle and gluconeogenesis[J].The American Journal of Physiology,1999,277(3):E401-E407.
[49] EMHOFF C A W,MESSONNIER L A,HORNING M A,et al.Gluconeogenesis and hepatic glycogenolysis during exercise at the lactate threshold[J].Journal of Applied Physiology,2013,114(3):297-306.
[50] MY AĆG KA G,ROPKA-MOLIK K,CYWI AN＇G SKA A,et al.Molecular insights into the lipid-carbohydrates metabolism switch under the endurance effort in Arabian horses[J].Equine Veterinary Journal,2024,56(3):586-597.
[51] HARDIE D G,HAWLEY S A.AMP-activated protein kinase:The energy charge hypothesis revisited[J].BioEssays:News and Reviews in Molecular,Cellular and Developmental Biology,2001,23(12):1112-1119.
[52] LOOS C M M,DORSCH S C,ELZINGA S E,et al.A high protein meal affects plasma insulin concentrations and amino acid metabolism in horses with equine metabolic syndrome[J].The Veterinary Journal,2019,251:105341.
[53] TORRES N,TOBÓN-CORNEJO S,VELAZQUEZ-VILLEGAS L A,et al.Amino acid catabolism:An overlooked area of metabolism[J]. Nutrients,2023,15(15):3378.
[54] MCKENDRY J,STOKES T,MCLEOD J C,et al.Resistance exercise,aging,disuse,and muscle protein metabolism[J].Comprehensive Physiology,2021,11(3):2249-2278.
[55] NIE C,HE T,ZHANG W,et al.Branched chain amino acids:Beyond nutrition metabolism[J].International Journal of Molecular Sciences,2018,19(4):954.
[56] VAN LOON L J C.Leucine as a pharmaconutrient in health and disease[J]. Current Opinion in Clinical Nutrition and Metabolic Care,2012,15(1):71-77.
[57] TIPTON K D,WOLFE R R.Exercise,protein metabolism,and muscle growth[J].International Journal of Sport Nutrition and Exercise Metabolism,2001,11(1):109-132.
[58] LE MOYEC L,ROBERT C,TRIBA M N,et al.Protein catabolism and high lipid metabolism associated with long-distance exercise are revealed by plasma NMR metabolomics in endurance horses[J].PLoS One,2014,9(3):e90730.
[59] SCOPPETTA F,TARTAGLIA M,RENZONE G,et al.Plasma protein changes in horse after prolonged physical exercise:A proteomic study[J].Journal of Proteomics,2012,75(14):4494-4504.
[60] 翁锡全.运动时骨骼肌的能量供应过程[J].中国体育教练员,2014,22(2):38-39.WENG X Q.The energy supply process of skeletal muscle during exercise[J].China Sports Coaches,2014,22(2):38-39.(in Chinese)
[61] MENG S,ZHANG Y,LV S,et al.Comparison of muscle metabolomics between two Chinese horse breeds[J].Frontiers in Veterinary Science,2023,10:1162953.
[62] 马文军,张涛.运动减肥与肉碱的关系[J].武汉体育学院学报,2002,36(5):52-53.MA W J,ZHANG T.The relationship between exercise dieting and carnitine[J].Journal of Wuhan Institute of Physical Education,2002,36(5):52-53.(in Chinese)
[63] IZZO L T,TREFELY S,DEMETRIADOU C,et al.Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis[J].Science Advances,2023,9(18):eadf0115.
[64] SEWELL D A,HARRIS R C.Adenine nucleotide degradation in the thoroughbred horse with increasing exercise duration[J].European Journal of Applied Physiology and Occupational Physiology,1992,65(3):271-277.
[65] GARCIA E I C,ELGHANDOUR M M M Y,KHUSRO A,et al.Dietary supplements of vitamins E,C,and β-carotene to reduce oxidative stress in horses:An overview[J].Journal of Equine Veterinary Science,2022,110:103863.
[66] WILLIAMS C A,CARLUCCI S A.Oral vitamin E supplementation on oxidative stress,vitamin and antioxidant status in intensely exercised horses[J].Equine Veterinary Journal Supplement,2006,36:617-621.
[67] TAYLOR S D,HART K A,VAUGHN S,et al.Effects of intravenous administration of ascorbic acid (vitamin C) on oxidative status in healthy adult horses[J].Journal of Veterinary Internal Medicine,2024,38(1):460-468.
[68] FINNO C J,VALBERG S J.A comparative review of vitamin E and associated equine disorders[J].Journal of Veterinary Internal Medicine,2012,26(6):1251-1266.
[69] BOS A,COMPAGNIE E,LINDNER A.Effect of racing on blood variables in Standardbred horses[J].Veterinary Clinical Pathology,2018,47(4):625-628.
[70] ZHANG Y,XUN P,WANG R,et al.Can magnesium enhance exercise performance?[J].Nutrients,2017,9(9):946.
[71] 马巍.多组学联合分析蒙古马运动前后耐力适应性机制研究[D].呼和浩特：内蒙古农业大学,2024.MA W.Multi-omics joint analysis of the mechanisms of endurance adaptations pre- and post-exercise in Mongolian horses[D].Hohhot:Inner Mongolia Agricultural University,2024.(in Chinese)
[72] MACH N,RAMAYO-CALDAS Y,CLARK A,et al.Understanding the response to endurance exercise using a systems biology approach:Combining blood metabolomics,transcriptomics and miRNomics in horses[J].BMC Genomics,2017,18(1):187.

Advances in Equine Exercise Metabolome and Its Associated Metabolic Pathways

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