家畜肌内脂肪沉积的营养调控研究进展

doi:10.16431/j.cnki.1671-7236.2025.10.019

Abstract

Abstract: Intramuscular fat (IMF) is a key indicator affecting muscle quality,but due to the timing of fat deposition.IMF deposition requires a long feeding cycle and high production cost.It is a hot and difficult point in the industry to study the use of nutrition regulation means to control more fat deposition as IMF.This review briefly describes the formation and composition of IMF,the key factors regulating IMF deposition (including peroxisome proliferator-activated receptors,fatty acid-binding proteins and sterol regulatory element-binding proteins,etc.),and analyzes the effects of dietary energy level and nutritional factors such as starch type,vitamin A,amino acids,natural plants and their extracts on IMF deposition in livestock.The authors suggest using multi-omics technology to analyze the differences of lipid metabolism in different parts of adipose tissue,combined with nutritional regulation and omics technology to further clarify the molecular mechanism of various nutritional factors,and study the effect of the synergy of multiple nutritional factors,so as to provide innovative nutritional regulation and control scheme for IMF deposition in livestock,and help the production of high-quality livestock products.

Key words: intramuscular fat; fat metabolism; nutritional regulation; livestock production

CLC Number:

S811.2

YANG Ming, ZHANG Xianglun, JI Kaixi, SHENG Qingkai, ZHAO Hongbo, WANG Zhonghua. Research Progress on Nutritional Regulation of Intramuscular Fat Deposition in Livestock[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(10): 4734-4741.

References

[1] FRANK D，BALL A，HUGHES J，et al.Sensory and flavor chemistry characteristics of Australian beef:Influence of intramuscular fat，feed，and breed[J].Journal of Agricultural and Food Chemistry，2016，64(21)：4299-4311.
[2] ZHOU Y，CHEN Z，HE X F.Association between complex flavor development and changes in meat structure during cooking:Histological imaging analysis[J].ACS Food Science & Technology，2024，4(12)：2937-2945.
[3] BLEICHER J，EBNER E E，BAK K H.Formation and analysis of volatile and odor compounds in meat—A review[J].Molecules，2022,27(19):6703.
[4] ZHANG D，CHU M，Ge Q，et al.Effects of dietary energy levels on growth performance，serum metabolites，and meat quality of Jersey cattle-yaks[J].Foods，2024，13(16):2527.
[5] 李海海.维生素A对哺乳期滩羔羊生长性能、血液生化指标及肌内脂肪沉积的影响[D].银川：宁夏大学，2022. LI H H.Effect of vitamin A on growth performance，blood biochemistry indices and intramusular fat deposition of lactation Tan lambs[D].Yinchuan:Ningxia University，2022.(in Chinese)
[6] ZHENG C，WAN M，GUO Q，et al.Glutamate increases the lean percentage and intramuscular fat content and alters gut microbiota in Shaziling pigs[J].Animal Nutrition，2025，20:110-119.
[7] YANG T，FENG F，ZHAN K，et al.Effect of the tea tree oil on growth performance，meat quality，serum biochemical indices，and antioxidant capacity in finishing pigs[J].Frontiers in Veterinary Science，2022，91:916625.
[8] TAN Z，JIANG H.Molecular and cellular mechanisms of intramuscular fat development and growth in cattle[J].International Journal of Molecular Sciences，2024，25(5):2520.
[9] HAUSMAN G J，BASU U，DU M，et al.Intermuscular and intramuscular adipose tissues:Bad vs.good adipose tissues[J].Adipocyte，2014，3(4):242-255.
[10] 李鹤琼，罗海玲.反刍动物肌内脂肪及脂肪酸调控研究进展[J].中国畜牧杂志，2019，55(8):1-5. LI H Q，LUO H L.Advances in regulation of intramuscular fat and fatty acids in ruminants[J].Chinese Journal of Animal Science，2019，55(8):1-5.(in Chinese)
[11] 马勇，罗海玲，王怡平，等.肌内脂肪含量和脂肪酸组成对绵羊肉品质的影响[J].现代畜牧兽医，2016，12(9):25-28. MA Y，LUO H L，WANG Y P，et al.Effects of intramuscular fat content and fatty acid composition on quality traits of sheep meat[J].Modern Journal of Animal Husbandry and Veterinary Medicine，2016，12(9):25-28.(in Chinese)
[12] LI W R，ZHANG C，WANG J.PPARs:Modulating lipotoxicity and thus inhibiting fibrosis[J].Hormones，2025，24(1):85-97.
[13] CHRISTOFIDES A，KONSTANTINIDOU E，JANI C,et al.The role of peroxisome proliferator-activated receptors (PPAR) in immune responses[J].Metabolism，2021，114:154338.
[14] AKBARI R，YAGHOOTI H，JALALI M T，et al.Capparis spinosa improves non-alcoholic steatohepatitis through down-regulating SREBP-1c and a PPARα-independent pathway in high-fat diet-fed rats[J].BMC Research Notes，2022，15(1):315.
[15] SCHUMACHER M，DELCURTO-WYFFELS H，THOMSON J，et al.Fat deposition and fat effects on meat quality—A review[J].Animals，2022，12(12)：1550.
[16] PARK S，BAEK I-J，RYU J H，et al.PPARα-ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis[J].Nature Communications，2022，13(1):3.
[17] WANG Y，NAKAJIMA T，GONZALEZ F J，et al.PPARs as metabolic regulators in the liver:Lessons from liver-specific PPAR-null mice[J].International Journal of Molecular Sciences，2020，21(6):2061.
[18] ZHU J，NIE G，DAI X，et al.Activating PPARβ/δ-mediated fatty acid β-oxidation mitigates mitochondrial dysfunction co-induced by environmentally relevant levels of molybdenum and cadmium in duck kidneys[J].Biological Trace Element Research，2025，203(7):3870-3883.
[19] 姚艳，王宗保，唐朝克.PPARs在长链脂肪酸调控能量代谢中的作用[J].生理科学进展，2016，47(1):1-6. YAO Y，WANG Z B，TANG C K.PPARs mediate the regulation of energy metabolism by long-chain fatty acids[J].Progress in Physiological Sciences，2016，47(1):1-6.(in Chinese)
[20] 李银，韦洋洋，蒋钦杨，等.动物肌内脂肪沉积的影响因素及其分子机制[J].动物营养学报，2024，36(3):1502-1514. LI Y，WEI Y Y，JIANG Q Y，et al.Affecting factors of intramuscular fat deposition in animals and their molecular mechanisms[J].Chinese Journal of Animal Nutrition，2024，36(3):1502-1514.(in Chinese)
[21] WANG C，MU T，FENG X，et al.Study on fatty acid binding protein in lipid metabolism of livestock and poultry[J].Research in Veterinary Science，2023，158(1):185-195.
[22] LIANG M Y，HOU X M，QU B，et al.Functional analysis of FABP3 in the milk fat synthesis signaling pathway of dairy cow mammary epithelial cells[J].In Vitro Cellular & Developmental Biology-Animal，2014，50(9):865-873.
[23] MALGWI I H,HALAS V,GRVNVALD P,et al.Genes related to fat metabolism in pigs and intramuscular fat content of pork:A focus on nutrigenetics and nutrigenomics[J].Animals,2022,12(2):150.
[24] LIU R，LIU X，BAI X，et al.Different expression of lipid metabolism-related genes in Shandong Black cattle and Luxi cattle based on transcriptome analysis[J].Scientific Reports，2020，10(1):21915.
[25] 柏琴.不同年龄牦牛肌内脂肪(IMF)沉积规律及其脂肪代谢机制研究[D].成都：西南民族大学，2023. BAI Q.Intramuscular fat (IMF) deposition pattern and its fat metabolism mechanism in yaks of different ages[D].Chengdu:Southwest Minzu University，2023.(in Chinese)
[26] ZHAO Q，LIN X，WANG G.Targeting SREBP-1-mediated lipogenesis as potential strategies for cancer[J].Frontiers in Oncology，2022，12:952371.
[27] SHIMANO H，HORTON J D，HAMMER R E，et al.Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a[J].Journal of Clinical Investigation，1996，98(7):1575-1584.
[28] ZHU L，DU W，LIU Y，et al.Prolonged high-glucose exposure decreased SREBP-1/FASN/ACC in Schwann cells of diabetic mice via blocking PI3K/Akt pathway[J].Journal of Cellular Biochemistry，2018，120(4):5777-5789.
[29] BROWNSEY R W，BOONE A N，ELLIOTT J E，et al.Regulation of acetyl-CoA carboxylase[J].Biochemical Society Transactions，2006，34:223-227.
[30] WITKOWSKI A，JOSHI A K，SMITH S.Coupling of the de novo fatty acid biosynthesis and lipoylation pathways in mammalian mitochondria[J].Journal of Biological Chemistry，2007，282(19):14178-14185.
[31] 曾方圆.锶介导SIRT1/SREBP通路调控奶牛肝细胞脂质代谢的机制研究[D].杨凌：西北农林科技大学，2023. ZENG F Y.The mechanism of strontium regulating the lipid metabolism of bovine hepatocytes via the SIRT1/SREBP pathway[D].Yangling:Northwest A&F University，2023.(in Chinese)
[32] 王鸿泽.日粮能量水平对舍饲育肥牦牛生产性能、瘤胃发酵及肌内脂肪代谢的影响[D].雅安：四川农业大学，2015. WANG H Z，Effects of dietary energy connection on performance，rumen fermentation and intramuscular fat metabolism in yaks fed indoors[D].Ya’an:Sichuan Agricultural University，2015.(in Chinese)
[33] KANG K，MA J，WANG H，et al.High-energy diet improves growth performance，meat quality and gene expression related to intramuscular fat deposition in finishing yaks raised by barn feeding[J]. Veterinary Medicine and Science，2020，6(4):755-765.
[34] ZHANG H，GUAN W.The response of gene expression associated with intramuscular fat deposition in the longissimus dorsi muscle of Simmental×Yellow breed cattle to different energy levels of diets[J].Animal Science Journal，2019，90(4):493-503.
[35] 王丽.饲粮能量水平和来源对育肥猪骨骼肌脂肪代谢相关基因表达的影响[D].雅安：四川农业大学，2009. WANG L.Effect of dietary energy levels and sources on muscle lipid metabolism genes expression in pigs[D].Ya’an:Sichuan Agricultural University，2009(in Chinese)
[36] 李岫怡，杨桂芹，郭东新.不同来源淀粉的组成、结构及其在动物生产上的应用研究进展[J].动物营养学报，2019，31(3):1053-1060. LI X Y，YANG G Q，GUO D X.Research progress on composition，structure and application of different starch sources in animal production[J].Chinese Journal of Animal Nutrition,2019，31(3):1053-1060.(in Chinese)
[37] YU M，LI Z，RONG T，et al.Different dietary starch sources alter the carcass traits，meat quality，and the profile of muscle amino acid and fatty acid in finishing pigs[J].Journal of Animal Science and Biotechnology，2020，11(1):78.
[38] 蒲俊宁，王华杰，陈代文，等.饲粮直链/支链淀粉比对育肥猪生长性能、营养物质表观消化率、肠道食糜菌群数量与挥发性脂肪酸浓度以及肌内脂肪含量的影响[J].动物营养学报，2018，30(12):4874-85. PU J N，WANG H J，CHEN D W，et al.Effects of dietary amylose/amylopectin ratio on growth performance，nutrient apparent dgestibility，intestinal microflora number and volatile fatty acid concentrations and intramuscular fat content of finishing pigs[J]. Chinese Journal of Animal Nutrition，2018，30(12):4874-85.(in Chinese)
[39] FANG L，JIANG X，SU Y，et al.Long-term intake of raw potato starch decreases back fat thickness and dressing percentage but has no effect on the longissimus muscle quality of growing-finishing pigs[J].Livestock Science，2014，170:116-123.
[40] SONG P，HUO G，FENG J，Et al.Intramuscular vitamin A injection in newborn lambs enhances antioxidant capacity and improves meat quality[J].Frontiers in Veterinary Science，2023，10(1):1-9.
[41] YU X，MA Y，LUO Y，et al.Neonatal vitamin A administration increases intramuscular fat by promoting angiogenesis and preadipocyte formation[J].Meat Science，2022，191:108847.
[42] 张幸开.维生素A对肉牛肌内脂肪沉积及ACC/HSL、PPARγ基因表达的影响[D].杨凌：西北农林科技大学，2005. ZHANG X K.The influence of intramuscular fat deposit and gene expression of ACC/HSL and PPARγ with the supplementation of vitamin A in beef cattle[D].Yangling:Northwest A&F University，2005.(in Chinese)
[43] 胡诚军，张婷，张涛，等.饲粮添加亮氨酸和谷氨酸对肥育猪肌肉脂肪酸组成和脂质代谢相关基因表达的影响[J].动物营养学报，2018，30(5):1798-1806. HU C J，ZHANG T，ZHANG T，et al.Effects of dietary leucine and glutamic acid on fatty acid composition and expression of lipid metabolism-related genes in muscle of finishing pigs[J].Chinese Journal of Animal Nutrition，2018，30(5):1798-1806.(in Chinese)
[44] YIN Y，LIU Y，DUAN G，et al.The effect of dietary leucine supplementation on antioxidant capacity and meat quality of finishing pigs under heat stress[J].Antioxidants，2022，11(7):1373.
[45] DOU L，LIU C，SU R，et al.Effects of dietary arginine supplementation on muscle structure，meat characteristics and lipid oxidation products in lambs and its potential mechanisms of action[J].Meat Science，2024，216:109581.
[46] CHEN X，LUO Y，JIA G，et al.The effect of arginine on the Wnt/β-catenin signaling pathway during porcine intramuscular preadipocyte differentiation[J].Food & Function，2017，8(1):381-386.
[47] LUO Y，ZHANG X，ZHU Z，et al.Surplus dietary isoleucine intake enhanced monounsaturated fatty acid synthesis and fat accumulation in skeletal muscle of finishing pigs[J].Journal of Animal Science and Biotechnology，2018，9(1):88.
[48] WU L，ZHANG H，NA L，et al.Methionine restriction at the post-weanling period promotes muscle fiber transition in piglets and improves intramuscular fat content in growing-finishing pigs[J].Amino Acids，2019，51(10-12):1657-1666.
[49] 朱雷.天然植物提取物对畜禽生产性能及肉品质应用研究[J].现代畜牧科技，2023，7:83-85. ZHU L.Study on the application of natural plant extracts to the productive performance and meat quality of livestock and poultry[J].Modern Animal Husbandry Science & Technology，2023，7:83-85.(in Chinese)
[50] ZHANG C，LUO J，YU B，et al.Effects of resveratrol on lipid metabolism in muscle and adipose tissues:A reevaluation in a pig model[J].Journal of Functional Foods，2015，14:590-595.
[51] ZHANG H Z，CHEN D W，HE J，et al.Long-term dietary resveratrol supplementation decreased serum lipids levels，improved intramuscular fat content，and changed the expression of several lipid metabolism-related miRNAs and genes in growing-finishing pigs[J].Journal of Animal Science，2019，97(4):1745-1756.
[52] 邓步皓，秦旭泽，张婷，等.日粮中添加沙棘果渣对肉羊肌内脂肪沉积及其关键基因和酶活力的影响[J].激光生物学报，2020，29(5):475-481. DENG B H，QIN X Z，ZHANG T，et al.Effect of dietary seabuckthorn pomace supplementation on intramuscular fat deposition related gene expression and enzyme activity in lambs[J].Acta Laser Biology Sinica，2020，29(5):475-481.(in Chinese)
[53] 张海波.紫苏籽提取物对育肥牛肌内脂肪沉积的影响[J].动物营养学报，2019，31(4):1897-1903. ZHANG H B.Effects of perilla seed extract on intramuscular fat deposition in fattening cattle[J].Chinese Journal of Animal Nutrition，2019，31(4):1897-1903.(in Chinese)
[54] 孙志伟.大豆黄酮对生长肥育猪生长性能、胴体性状和肉品质的影响[D].雅安：四川农业大学,2019. SUN Z W.Effects of daidzein on growth performance，carcass characteristics，and meat quality in growing-finishing pigs[D].Ya’an:Sichuan Agricultural University，2019(in Chinese)

Research Progress on Nutritional Regulation of Intramuscular Fat Deposition in Livestock

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	LAO Yingdi, HOU Caiqin, LI Xin, GUO Yiwen, HU Debao, GUO Hong, ZHANG Linlin, DING Xiangbin. Research Progress on Intramuscular Fat Deposition Related Genes in Livestock and Poultry [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2603-2611.
[2]	XIA Minglong, XIAO Yintao, ZHENG Saizhen, TAN Bie, YIN Yulong, CHEN Jiashun, YIN Jie. Analysis of Differentially Expressed Genes and Regulatory Pathways in Intramuscular Fat Deposition of Ningxiang Pigs at Different Developmental Stages [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(9): 3703-3714.
[3]	LONG Meihe, ZHENG Chuntian, CHEN Wei, JIN Chenglong. Research Progress on Feather Growth Mechanism and Nutritional Control of Waterfowl [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(5): 1868-1879.
[4]	GOU Danni, WANG Gang, SHEN Xuemei, NIE Liang, HUI Wenjing, GULIPARI Aikebai, YANG Yaling, LIAO Juan, YU Shigang. Polymorphism of LIPE Gene Exon 1 and Its Association with Body Weight and Intramuscular Fat Content in Muchuan Black-bone Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(12): 4973-4982.
[5]	LIANG Shasha, YU Nongqi, LU Ying, LI Tingting, YAN Shengfei, HUANG Jian, TAN Zhengzhun, HUANG Rongchun, LI Hui, PAN Weijun, QIN Guangsheng. Screening of Key Genes Related to Intramuscular Fat Deposition in Buffaloes Based on GEO Database and Bioinformatics Analysis [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(11): 4359-4369.
[6]	NIE Jingru, MA Li, YAN Dawei, DENG Jun, ZHANG Hao, ZHANG Bo, LIU Jinqiao, DONG Xinxing. Analysis of Differentially Expressed Genes and Regulation Pathways of Intramuscular Fat Deposition in Large Diqing Tibetan Pigs at Different Growth Stages [J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(8): 2855-2868.
[7]	WANG Xiaoli, WANG Xingxin, YANG Caimei, XIAO Yingping, YANG Hua, LYU Wentao. Analysis of Ileum Transcriptome Differences in Muscovy Ducks with Different Abdominal Fat Rates [J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(8): 2899-2909.
[8]	YANG Shuai, SHI Mingyue, LI Wenxia, YUN Jiale, SUN Di, LU Chang, YANG Yang, CAI Chunbo, GAO Pengfei, GUO Xiaohong, LI Bugao, CAO Guoqing. Screening and Expression Analysis of Genes Related to Porcine Intramuscular Fat Deposition [J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(5): 1651-1661.
[9]	YANG Juan, GUO Shuai, HAN Shichang, ZHANG Nian, ZHANG Feng, TAO Hu, XIONG Qi. Study on the Differences of Blood Indexes and Slaughter Performance Between 6-month-old Boer Goats and Macheng Black Goats [J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(4): 1332-1342.
[10]	HOU Junjie, SHI Zhuoyan, LIU Xiaoping, JI Xiang, CHU Xiaoran, SONG Zhen, WEN Fengyun. Research Progress on microRNA Regulation of Intramuscular Fat Deposition in Pigs [J]. China Animal Husbandry & Veterinary Medicine, 2022, 49(11): 4318-4326.
[11]	YU Shigang, WANG Gang, LIAO Juan, XIE Wei. Screening and Identification of the microRNAs Associated with Intramuscular Fat Deposition in Muchuan Black-bone Chicken [J]. China Animal Husbandry & Veterinary Medicine, 2021, 48(8): 2713-2726.
[12]	OU Xiuqiong, LI Rui, ZHANG Xiaochun, ZHONG Zhengze, XIE Huadong, LI Xing, BU Lijun, JING Shaohong, PENG Hong. Genetic Mechanism of Pig Muscle Fiber Property Formation and Intramuscular Fat Deposition [J]. China Animal Husbandry & Veterinary Medicine, 2021, 48(3): 925-931.
[13]	LI Jinghui, XING Siyuan, WANG Xicai, LI Qinghe, ZHAO Guiping, ZHANG Yonghong, WEN Jie, LIU Ranran. Screening of Candidate Genes Related to Intramuscular Fat Deposition in Chickens [J]. China Animal Husbandry & Veterinary Medicine, 2020, 47(6): 1828-1836.
[14]	LYU Yaning, HE Chenxin, LAN Lyutao. A Research Advances on the Relationship Between Intramuscular Fat and Meat Quality and Influence Factor of Intramuscular Fat in Pigs [J]. China Animal Husbandry & Veterinary Medicine, 2020, 47(2): 554-563.
[15]	ZHU Mengting, XIE Yifan, WANG Xiaolu, ZHAO Zongsheng. Developmental Changes of CAPN1 and H-FABP Genes Expression and Their Intramuscular Fat Content in Yellow Feather Broilers Under Free-range [J]. China Animal Husbandry & Veterinary Medicine, 2019, 46(5): 1413-1420.