胍基乙酸调控动物能量代谢及改善生产性能的研究进展

doi:10.16431/j.cnki.1671-7236.2025.10.014

Abstract

Abstract: Guanidinoacetic acid (GAA) is a key precursor for endogenous creatine synthesis and has attracted much attention in recent years due to its unique role in regulating animal energy metabolism.With the increasing demand for efficient and safe nutritional regulators in animal husbandry,the potential application of GAA is gradually becoming prominent.However,its large-scale application still faces scientific problems such as unclear dose-response relationships,unresolved metabolic molecular mechanisms,and insufficient long-term safety assessments.By regulating the phosphocreatine/creatine kinase system,GAA significantly improves the efficiency of skeletal muscle adenosine triphosphate (ATP) regeneration,enhances animal growth performance,and improves meat quality.GAA can enhance the body’s antioxidant capacity and insulin secretion function,optimize rumen fermentation efficiency.Compared with exogenous creatine,GAA has higher bioavailability (small intestine absorption rate ≥90%),rumen stability (degradation rate ≤ 10%,which can be further reduced to ≤5% if coated),and cost-effectiveness.The author provides theoretical basis for the scientific application of GAA in animal husbandry production from three dimensions:Metabolic regulation,industrial application,and mechanism of action,it also proposes innovative paths for the development of new nutritional regulators,which has important practical value in promoting the improvement and efficiency of animal husbandry.

Key words: guanidinoacetic acid; creatine; energy metabolism; growth performance; antioxidant capacity; feed additives

CLC Number:

S816.71

ZHU Wenshu, CHEN Yong, LIU Mengjian. Guanidinoacetic Acid Regulation of Animal Energy Metabolism and Improvement of Production Performance:A Review[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(10): 4688-4696.

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Guanidinoacetic Acid Regulation of Animal Energy Metabolism and Improvement of Production Performance:A Review

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