功能性添加剂对犬肠道健康的影响研究进展

doi:10.16431/j.cnki.1671-7236.2025.05.008

Abstract

Abstract: Dogs,due to their unique digestive physiological structure,metabolic characteristics,and inherent living habits,face a heightened risk of intestinal diseases.Especially for working dogs,which need to cope with various stress factors,the susceptibility to intestinal diseases further increases.Currently,functional additives play a pivotal role in the prevention and control of intestinal diseases in dogs.These additives,derived from biological enzymatic hydrolysates,plant extracts,microecological agents,and traditional Chinese medicine compounds,exert dual therapeutic and health-promoting effects on canine intestinal health through multiple mechanisms such as regulating intestinal flora balance,enhancing intestinal immune function,optimizing intestinal digestion and absorption,and reducing intestinal inflammation.They also actively promote the growth,development,metabolism,and immune enhancement of dogs.Therefore,the scientific and rational application of functional additives can be regarded as one of the effective strategies for preventing and treating intestinal diseases in dogs.The authors have summarized the existing research findings on the effects of functional additives on animal intestinal health,delved into the classification,application,and specific effects of functional additives on intestinal health,and integrated scattered research arguments,providing a reference for subsequent theoretical and experimental research by practitioners.

Key words: functional additive; dog; intestinal health; nutrition; immunity

CLC Number:

S816.7

ZHAO Wenhao, ZHAI He, WANG Yao, QIN Zhipeng, YUE Zihao. Research Progress on the Effects of Functional Additives on Intestinal Health in Dogs[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2023-2034.

References

[1] 陈宝江,刘树栋,韩帅娟.宠物肠道健康与营养调控研究进展[J].饲料工业,2020,41(13):9-13.CHEN B J,LIU S D,HAN S J.Research development of nutritional regulation and intestinal health of pets[J].Feed Industry,2020,41(13):9-13.(in Chinese)
[2] 夏俊良,崔玉凌,邓百川.益生菌调控犬肠道健康的研究进展[J].广东饲料,2024,33(4):34-38.XIA J L,CUI Y L,DENG B C.Research progress of probiotics regulating intestinal health of dog[J].Guangdong Feed,2024,33(4):34-38.(in Chinese)
[3] 郑晓蔓,林琳,唐陆平,等.犬和猫肠道菌群研究进展[J].动物医学进展,2021,42(8):78-83.ZHENG X M,LIN L,TANG L P,et al.Progress on intestinal microbiota of dogs and cats[J].Progress in Veterinary Medicine,2021,42(8):78-83.(in Chinese)
[4] KELLY S.Pet owner attitudes toward natural nutrition[J].Veterinary Medicine,2010,105(11)：490-498.
[5] HAN X,MA Y,DING S,et al.Regulation of dietary fiber on intestinal microorganisms and its effects on animal health[J].Animal Nutrition,2023,3:356-369.
[6] 杨敏敏,吴孝杰,巨玉鑫,等.益生菌对犬肠道健康的影响研究进展[J].中国畜牧杂志,2024,60(6):44-48.YANG M M,WU X J,JU Y X,et al.Research progress on the effects of probiotics on canine intestinal health[J].Chinese Journal of Animal Science,2024,60(6):44-48.(in Chinese)
[7] CARTER R A,BAUER J E,KERSEY J H,et al.Awareness and evaluation of natural pet food products in the United States[J].Journal of the American Veterinary Medical Association,2014,245(11):1241-1248.
[8] 谢广杰.草鱼下脚料酶解产物制备猫粮诱食剂的研究[D].南京:南京农业大学,2020.XIE G J.Preparation of cat food palatability enhancer with enzymolysis products from grass carp offal[D].Nanjing:Nanjing Agricultural University,2020.(in Chinese)
[9] 闫静芳.鲢鱼下脚料制备新型猫粮诱食剂的研究[D].南京:南京农业大学,2016.YAN J F.Preparation of cat food palatability enhancer from silver carp scraps[D].Nanjing:Nanjing Agricultural University,2016.(in Chinese)
[10] 刘策,林振国,徐振华,等.含有不同诱食剂的猫粮的挥发成分对猫适口性的影响[J].饲料研究,2020,43(7):62-65.LIU C,LIN Z G,XU Z H,et al.The volatile compounds profiles of feline diet with flavour enhancers and its palatability for pet cats[J]. Feed Research,2020,43(7):62-65.(in Chinese)
[11] 郭艳霞.酶解鸡肉制备热反应型犬粮诱食剂的改进及其应用[D].南京:南京农业大学,2016.GUO Y X.Improvement and application of dog food attractant prepared with chicken by enzymatic hydrolysis reaction and thermal reaction[D].Nanjing:Nanjing Agricultural University,2016.(in Chinese)
[12] 张嘉祺,闵德栋,刘云国.植物精油抑菌机制及其在食用菌保鲜中的应用进展[J].中国果菜,2024,44(4):9-13.ZHANG J Q,MIN D D,LIU Y G.Advances on the antibacterial mechanism of plant essential oil and its application on preservation of edible mushrooms[J].China Fruit & Vegetable,2024,44(4):9-13.(in Chinese)
[13] 曾建腾,范志聪,张永亮.植物提取物改善畜禽肠道菌群结构的研究进展[J].现代畜牧兽医,2023,8:70-74.ZENG J T,FAN Z C,ZHANG Y L.Research progress of plant extracts improving intestinal flora structure of livestock and poultry[J].Modern Journal of Animal Husbandry and Veterinary Medicine,2023,8:70-74.(in Chinese)
[14] BIANCHINI A.Use of essential oils and plant extracts to control microbial contamination in pet food products[J].Food Processing & Technology,2014,5(8):1-9.
[15] 赵艳丽,彭卓亚,徐永平,等.肉桂醛在猪生产中的应用研究进展[J].中国畜牧兽医,2024,51(10):4373-4382.ZHAO Y L,PENG Z Y,XU Y P,et al.Research progress on the application of Cinnamaldehyde in pig production[J].China Animal Husbandry & Veterinary Medicine,2024,51(10):4373-4382.(in Chinese)
[16] SMITH-PALMER A,STEWART J,FYFE L.Antimicrobial properties of plant essential oils and essences against five important food-borne pathogens[J].Letters in Applied Microbiology,1998,26(2):118-122.
[17] 胡蝶,阿拉腾珠拉,程志钱,等.褐藻寡糖对肉鸡生长性能、免疫器官指数、血清抗氧化指标和肠道健康的影响[J].动物营养学报,2024,36(4):2331-2343.HU D,ALA T Z L,CHENG Z Q,et al.Effects of alginate oligosaccharide on growth performance,immune organ indices,serum antioxidant indices and intestinal health of broilers[J].Chinese Journal of Animal Nutrition,2024,36(4):2331-2343.(in Chinese)
[18] 周卫东,张永平,范树强,等.补中益气汤合六味地黄汤治疗慢性肾小球肾炎临床观察[J].光明中医,2021,36(11):1805-1807.ZHOU W D,ZHANG Y P,FAN S Q,et al.Clinical observation on Buzhong Yiqi decoction and Liuwei Dihuang decoction in the treatment of chronic glomerulonephritis[J].Guangming Journal of Chinese Medicine,2021,36(11):1805-1807.(in Chinese)
[19] 金恩鸿,梁晚枫,鞠重基,等.8味中药复方灌肠治疗犬非感染性腹泻[J].延边大学农学学报,2015,37(4):344-348.JIN E H,LIANG W F,JU Z J,et al.Treatment of non-infectious diarrhea in dogs with eight Chinese herbal compound enema[J].Journal of Agricultural Science Yanbian University,2015,37(4):344-348.(in Chinese)
[20] 杨帆,夏子威,刘厚辉,等.中药肾茶对家猫夏季饮水和血清尿素含量的影响[J].上海师范大学学报:自然科学版,2021,50(2):181-185.YANG F,XIA Z W,LIU H H,et al.The effect of Chinese herbal medicine Orthosiphon aristatus on water drinking and serum urea content of domestic cat in summer[J].Journal of Shanghai Normal University(Natural Sciences),2021,50(2):181-185.(in Chinese)
[21] 李占占,李勇,丁雪,等.中药处方犬粮的安全性评价及其对犬创伤恢复能力的影响[J].安徽农业科学,2014,21:7095-7098.LI Z Z,LI Y,DING X,et al.Safety evaluation of traditional Chinese medicine prescription dog food and its effect on the trauma recovery ability of dogs[J].Journal of Anhui Agricultural Sciences,2014,21:7095-7098.
[22] XU H,ZHAO F,HOU Q,et al.Metagenomic analysis revealed beneficial effects of probiotics in improving the composition and function of the gut microbiota in dogs with diarrhoea[J].Food & Function,2019,10(5):2618-2629.
[23] 王志华,贾俊鹏,MATJEKE R S,等.微生态制剂调控比格幼犬生长性能和肠道菌群的研究[J].中国畜牧兽医，2022,49(2):510-520.WANG Z H,JIA J P,MATJEKE R S,et al.Study on the growth performance and intestinal flora of Beagle puppies regulated by probiotics[J].China Animal Husbandry & Veterinary Medicine,2022,49(2):510-520.(in Chinese)
[24] 毕景成,王新颖,黎介寿.肠碱性磷酸酶在肠屏障中作用的研究进展[J].肠外与肠内营养,2015,22(4):244-247.BI J C,WANG X Y,LI J S.Research progresses of intestinal alkaline phosphatase in intestinal barrier maintenance[J].Parenteral & Enteral Nutrition,2015,22(4):244-247.(in Chinese)
[25] 沈旸.鲟鱼酶解产物的制备及抗炎活性的研究[D].镇江:江苏大学,2021.SHEN Y.Study on the preparation of sturgeon hydrolysates and its anti-inflammatory activity[D].Zhenjiang:Jiangsu University 2021.(in Chinese)
[26] SZCZEPANIL M P,M GOŁY AŃG SKI,P WILKOŁEK,et al.Evaluation of a hydrolysed salmon and pea hypoallergenic diet application in dogs and cats with cutaneous adverse food reaction[J].Polish Journal of Veterinary Sciences,2022,25(1):67-73.
[27] 白雅婷.海参性腺酶解产物对实验动物肠道微生物的影响[D].厦门:集美大学,2018.BAI Y T.The effects of enzymatic hydrolysates of sea cucumber gonads on intestinal microbiota of laboratory animals[D].Xiamen:Jimei University,2018.(in Chinese)
[28] 赵梦迪,李光玉,刘可园,等.饲粮和益生菌对犬、猫肠道菌群影响的研究进展[J].动物营养学报,2022,34(11):6817-6829.ZHAO M D,LI G Y,LIU K Y,et al.Research progress on effects of diet and probiotics on gut microbiota in dogs and cats[J].Chinese Journal of Animal Nutrition,2022,34(11):6817-6829.(in Chinese)
[29] 王洪.赭曲霉毒素A和呕吐毒素的肠毒性及其相关机制研究[D].南京:南京农业大学,2019.WANG H.The intestinal toxicity of OTA or DON,and the potential mechanisms[D].Nanjing:Nanjing Agricultural University,2019.(in Chinese)
[30] SCARSELLA E,CINTIO M,IACUMIN L,et al.Interplay between neuroendocrine biomarkers and gut microbiota in dogs supplemented with grape proanthocyanidins:Results of dietary intervention study[J].Animals (Basel),2020,10(3):531.
[31] LI Y,RAHMAN S U,HUANG Y,et al.Green tea polyphenols decrease weight gain,ameliorate alteration of gut microbiota,and mitigate intestinal inflammation in canines with high-fat-diet-induced obesity[J].Journal of Nutritional Biochemistry,2020,78:108324.
[32] UYANGA V A,AMEVOR F K,LIU M,et al.Potential implications of citrulline and quercetin on gut functioning of monogastric animals and humans:A comprehensive review[J].Nutrients,2021,13(11):3782.
[33] YAN X,ZHAI Y,ZHOU W,et al.Intestinal flora mediates antiobesity effect of rutin in high-fat-diet mice[J].Molecular Nutrition & Food Research,2022,66(14):e2100948.
[34] BAUER B W,GANGADOO S,BAJAGAI Y S,et al.Oregano powder reduces Streptococcus and increases SCFA concentration in a mixed bacterial culture assay[J].PLoS One,2019,14(12):e0216853
[35] CHEW B P,PARK J S,WENG B C,et al.Dietary beta-carotene is taken up by blood plasma and leukocytes in dogs[J].Journal of Nutrition,2000,130(7):1788-1791.
[36] CHEW B P,PARK J S,WENG B C,et al.Dietary beta-carotene stimulates cell-mediated and humoral immune response in dogs[J].Journal of Nutrition,2000,130(8):1910-1913.
[37] HALL J A,PICTON R A,FINNERAN P S,et al.Dietary antioxidants and behavioral enrichment enhance neutrophil phagocytosis in geriatric Beagles[J].Veterinary Immunology and Immunopathology,2006,113(1-2):224-233.
[38] LILLEHOJ H S,KIM D K,BRAVO D M,et al.Effects of dietary plant-derived phytonutrients on the genome-wide profiles and coccidiosis resistance in the broiler chickens[J].BMC Proceedings,2011,5(Suppl4):S34.
[39] 赵人杰,白芯嫣,项璐,等.大蒜多糖对健康小鼠肠道菌群及免疫功能的影响[J].中国食品学报,2023,23(8):132-141.ZHAO R J,BAI X Y,XIANG L,et al.Effect of garlic polysaccharide on intestinal flora and immune function in healthy mice[J].Journal of Chinese Institute of Food Science and Technology,2023,23(8):132-141.(in Chinese)
[40] CHENG Y,LIU Y,CHEN D,et al.Dual effects of quercetin on protein digestion and absorption in the digestive tract[J].Food Chemistry,2021,358:129891.
[41] 郭爱伟,熊春梅,周杰珑,等.植物提取物对家禽肠道健康的调控及其作用机制[J].动物营养学报,2017,29(8):2613-2621.GUO A W,XIONG C M,ZHOU J L,et al.Regulation of poultry gut health by plant extracts and its mechanisms[J].Chinese Journal of Animal Nutrition,2017,29(8):2613-2621.(in Chinese)
[42] 邹垚,韩崇选.哺乳动物肠道微生物与碳水化合物的互作及其影响[J].应用生态学报,2020,31(11):3959-3968.ZOU Y,HAN C X.Interaction between intestinal microorganisms and carbohydrates of mammals and its influence[J].Chinese Journal of Applied Ecology,2020,31(11):3959-3968.(in Chinese)
[43] 何贝贝,姜建阳,于光辉,等.丝兰提取物对断奶仔猪生长性能、血清抗氧化和免疫指标、粪便中氮磷排放量及微生物数量的影响[J].动物营养学报,2017,29(8):2791-2799.HE B B,JIANG J Y,YU G H,et al.Effects of Yucca schidigera extract on growth performance,serum antioxidant and immune indexes,fecal nitrogen and phosphorus emission and microorganism number of weaner piglets[J].Chinese Journal of Animal Nutrition,2017,29(8):2791-2799.(in Chinese)
[44] 周霞,张海滨,周明东,等.四种植物提取物对肉鸡生长性能、肠道及排泄物生化指标的影响[J].山东农业科学,2011,11:89-93.ZHOU X,ZHANG H B,ZHOU M D,et al.Effects of four plant extracts on growth performance of broilers and biochemical indicators of intestinal contents and excreta[J].Shandong Agricultural Sciences,2011,11:89-93.(in Chinese)
[45] LI D,WU H,DOU H,et al.Microcapsule of sweet orange essential oil changes gut microbiota in diet-induced obese rats[J].Biochemical and Biophysical Research Communications,2018,505(4):991-995.
[46] 张君成,梁华,王燕,等.乌梅药理作用研究进展[J].辽宁中医药大学学报,2021,23(8):122-126.ZHANG J C,LIANG H,WANG Y,et al.Research progress of pharmacological action of Wumei[J].Journal of Liaoning University of Traditional Chinese Medicine,2021,23(8):122-126.(in Chinese)
[47] 江健,许倩楠,车莉,等.荷叶中生物碱类化合物及其降血脂活性研究[J].中国中药杂志,2024,49(19):5238-5243.JIANG J,XU Q N,CHE L,et al.Alkaloid compounds in Nelumbinis folium and their hypolipidemic effect[J].China Journal of Chinese Materia Medica,2024,49(19):5238-5243.(in Chinese)
[48] 鲁慧杰,陈卫东,田志梅,等.丝兰提取物生理功能及其在养殖生产上的应用[J].动物营养学报,2019,31(5):1990-2001.LU H J,CHEN W D,TIAN Z M,et al.Physiological function of yucca extract and its applications in husbandry production[J].Chinese Journal of Animal Nutrition,2019,31(5):1990-2001.(in Chinese)
[49] 张仪华,党瑛,杭榆,等.大蒜素抑制凝血酶诱导的大鼠血小板聚集研究[J].中国中西医结合杂志,1995,S1:82-84.ZHANG Y H,DANG Y,HANG Y,et al.Study on inhibiting mechanism of allicin on thrombin induced platelet aggregation in rats[J].Chinese Journal of Integrated Traditional and Western Medicine,1995,S1:82-84.
[50] 李新方,李现贵,马志强,等.薄荷脑鼻腔原位凝胶剂的制备及安全性研究[J].药学实践杂志,2017,35(4):321-324.LI X F,LI X G,MA Z Q,et al.An in situ gel system for nasal delivery of menthol:Preparation and safety evaluation[J].Journal of Pharmaceutical and Service,2017,35(4):321-324.(in Chinese)
[51] 刘灿,蒋丽艳,孙宇,等.中药与肠道菌群的相互作用研究进展[J].齐齐哈尔医学院学报,2024,45(1):86-89.LIU C,JIANG L Y,SUN Y,et al.Research progress on interaction between traditional Chinese medicine and gut microbiota[J]. Journal of Qiqihar Medical University,2024,45(1):86-89.(in Chinese)
[52] WU D T,YUAN Q,GUO H,et al.Dynamic changes of structural characteristics of snow chrysanthemum polysaccharides during in vitro digestion and fecal fermentation and related impacts on gut microbiota[J].Food Research International,2021,141:109888.
[53] 董汉琦.陈皮对犬肠道菌群及脂质代谢调控的研究[D].武汉:华中农业大学,2020.DONG H Q.Study of Chenpi on the regulation of internal flora and lipid metabolism in dogs[D].Wuhan:Huazhong Agricultural University,2020.(in Chinese)
[54] DUNCAN S H,LOUIS P,THOMSON J M,et al.The role of pH in determining the species composition of the human colonic microbiota[J].Environmental Microbiology,2009,11(8):2112-2122.
[55] 杨志华,邓柳颐,李冬梅,等.中药复方对肠道微生态调节作用的研究[J].西部中医药,2020,33(9):166-168.YANG Z H,DENG L Y,LI D M,et al.Study on the effects of herbal compound prescription on the regulation of intestinal microecology[J].Western Journal of Traditional Chinese Medicine,2020,33(9):166-168.(in Chinese)
[56] 王尧,陈果,张仕杰,等.中药通过调节肠道微生物-肠免疫轴治疗溃疡性结肠炎研究进展[J].中草药,2024,55(22):7857-7869.WANG Y,CHEN G,ZHANG S J,et al.Research progress on traditional Chinese medicine in treatment of ulcerative colitis by regulating intestinal microbiota-gut immune axis[J].Chinese Traditional and Herbal Drugs,2024,55(22):7857-7869.(in Chinese)
[57] 舒迎霜,王承志,李思婷,等.黄芪多糖对犬血清中白介素水平及肠道Toll样受体信号通路的影响[J].西北农林科技大学学报(自然科学版),2021,49(5):16-23.SHU Y S,WANG C Z,LI S T,et al.Effect of Astragalus polysaccharide on serum interleukin levels and intestinal Toll-like receptor signaling pathway in canines[J].Journal of Northwest A&F University(Natural Science Edition),2021,49(5):16-23.(in Chinese)
[58] 黎敏,米本中,刘莉,等.四磨汤口服液药理及临床应用研究进展[J].中南药学,2020,18(12):2031-2036.LI M,MI B Z,LIU L,et al.Research progress in pharmacology and clinical application of Simotang oral liquid[J].Central South Pharmacy,2020,18(12):2031-2036.(in Chinese)
[59] 赵旭龙.大黄、厚朴和枳实治疗肠梗阻的系统药理学研究[D].大连:大连理工大学,2020.ZHAO X L.Systems pharmacology study of rhubarb,magnolia and Citrus aurantium in treating ileus[D].Dalian:Dalian University of Technology,2020.(in Chinese)
[60] 舒迎霜.黄芪多糖对犬肠道免疫机能的作用机理研究[D].合肥:安徽农业大学,2021.SHU Y S.Mechanism of Astragalus polysaccharide on intestinal immune function in canines[D].Hefei:Anhui Agricultural University,2021.(in Chinese)
[61] 卢永慧,张立华,王京龙,等.基于网络药理学和分子对接探讨石榴皮治疗腹泻的作用机制[J].现代药物与临床,2023,38(10):2436-2443.LU Y H,ZHANG L H,WANG J L,et al.Mechanism of pomegranate peel in treatment of diarrhea based on network pharmacology and molecular docking[J].Drugs & Clinic,2023,38(10):2436-2443.(in Chinese)
[62] 姚婷,赵鋆.加味二陈汤对肥胖SD幼鼠肝脏组织Toll样受体4及肠道菌群的影响[J].江苏中医药,2021,53(9):67-72.YAO T,ZHAO Y.Effects of modified erchen decoction on TLR-4 in liver tissue and intestinal flora of obese juvenile SD rats[J].Jiangsu Journal of Traditional Chinese Medicine,2021,53(9):67-72.(in Chinese)
[63] 周雅萍,贺怡宁,汪兰慧,等.大黄调节“肠-肾轴”治疗慢性肾脏病的研究进展[J].中国医药导报,2024,21(29):53-56.ZHOU Y P,HE Y N,WANG L H,et al.Research progress on the regulation of "gut-kidney axis" by Rhei radix et Rhizoma in the treatment of chronic kidney disease[D].China Medical Herald,2024,21(29):53-56.(in Chinese)
[64] 李凤霞,胡致平,聂富意,等.马钱子治疗神经系统疾病研究进展[J].新中医,2020,52(13):17-20.LI F X,HU Z P,NIE F Y,et al.Research progress of semen strychni for nervous system diseases[J].New Chinese Medicine,2020,52(13):17-20.(in Chinese)
[65] KT F.Lily toxicity in the cat[J].Topics in Companion Animal Medicine,2010,25(4):213-217.
[66] 董文静,朱时明,刘清神.微生态制剂可调节犬肠道菌群[J].广东畜牧兽医科技,2021,46(3):27-30.DONG W J,ZHU S M,LIU Q S.Microecological agents regulate intestinal microflora in canines[J].Guangdong Journal of Animal and Veterinary Science,2021,46(3):27-30.(in Chinese)
[67] 李丹.饲粮中添加复合益生菌对产蛋不同阶段天府绿壳蛋鸡子宫部发育及蛋壳质量的影响[D].雅安:四川农业大学,2023.LI D.Effects of probiotics supplementation in the diet on uterine development and eggshell quality of Tianfu Green-shelled laying hens at different stages of egg production[D].Ya’an:Sichuan Agricultural University,2023.(in Chinese)
[68] 徐春晗.犬源益生芽孢杆菌的筛选及初步应用[D].长春:吉林农业大学,2018.XU C H.Screening and application of canine probiotic Bacillus[D].Changchun:Jilin Agricultural University,2018.(in Chinese)
[69] 王承智.犬源乳酸菌对致病性大肠杆菌感染犬肠道菌群及TLR5/NF-κB/NLRP3炎性通路的影响[D].合肥:安徽农业大学,2021.WANG C Z.Effects of Lactobacillus derived from canine on intestinal microflora and TLR5/NF-κB/NLRP3 inflammatory pathway in canines infected with pathogenic Escherichia coli[D].Hefei:Anhui Agricultural University,2021.(in Chinese)
[70] 陆锦南,赵春华,闵寒.犬尿喹啉酸在肠易激综合征中的作用机制[J].协和医学杂志,2023,14(2):353-358.LU J N,ZHAO C H,MIN H.Mechanism of action of kynurenic acid in irritable bowel syndrome[J].Medical Journal of Peking Union Medical College Hospital,2023,14(2):353-358.(in Chinese)
[71] MARIN I A,GOERTZ J E,REN T，et al.Microbiota alteration is associated with the development of stress-induced despair behavior[J].Scientific Reports,2017,7:43859.
[72] VALLADARES R,BOJILOVA L,POTTS A H,et al.Lactobacillus johnsonii inhibits indoleamine 2,3-dioxygenase and alters tryptophan metabolite levels in BioBreeding rats[J].FASEB Journal,2013,27(4):1711-1720.
[73] DESBONNET L,GARRETT L,CLARKE G,et al.The probiotic Bifidobacteria infantis:An assessment of potential antidepressant properties in the rat[J].Journal of Psychiatric Research,2008,43(2):164-174.
[74] RUDZKI L,OSTROWSKA L,PAWLAK D,et al.Probiotic Lactobacillus plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression:A double-blind,randomized,placebo controlled study[J].Psychoneuroendocrinology,2019,100:213-222.
[75] 李淼,何海娟,李忠秋,等.益生菌在畜禽肠道健康中的作用研究进展[J].饲料研究,2024,47(6):154-158.LI M,HE H J,LI Z Q,et al.Research progress on role of probiotics in intestinal health of livestock and poultry[J].Feed Research,2024,47(6):154-158.(in Chinese)
[76] 谢耀慧,李昕蓉,魏小成,等.乳酸菌生物利用的研究进展[J].华西药学杂志,2024,39(5):599-603.XIE Y H,LI X R,WEI X C,et al.Research progress on the biological application of lactic acid bacteria[J].West China Journal of Pharmaceutical Sciences,2024,39(5):599-603.(in Chinese)
[77] 王文胜,吴华,陈自鑫,等.微生态制剂作用机制及对畜禽免疫功能的影响[J].饲料研究,2024,47(4):143-147.WANG W S,WU H,CHEN Z X,et al.Mechanisms of action of probiotics and their effects on immune function of livestock and poultry[J].Feed Research,2024,47(4):143-147.(in Chinese)
[78] 刘海生,郭致君,段国臣,等.复合微生态制剂对母猪便秘改善及其生产性能的影响[J].中国动物保健,2017,19(2):79-82.LIU H S,GUO Z J,DUAN G C,et al.Effects of compound probiotics on the improve the sow constipation and production performance[J].China Animal Health,2017,19(2):79-82.(in Chinese)
[79] 蔡文涛,覃景芳,覃磊,等.饲用微生态制剂的研究进展及应用[J].湖北大学学报(自然科学版),2024,46(2):149-157.CAI W T,QIN J F,QIN L,et al.Progress and application of microecological preparations for feeding[J].Journal of Hubei University (Natural Science),2024,46(2):149-157.(in Chinese)
[80] 唐玉芬,范如英,盛剑秋.炎症性肠病与微生态制剂[J].胃肠病学和肝病学杂志,2012,21(8):782-784.TANG Y F,FAN R Y,SHENG J Q.Inflammatory bowel disease and microbial agents[J].Chinese Journal of Gastroenterology and Hepatology,2012,21(8):782-784.(in Chinese)
[81] 唐刚,袁伟杰.从生态学角度重新认识肠道菌群与肾脏疾病的关系[J].肾脏病与透析肾移植杂志,2020,29(2):176-180.TANG G,YUAN W J.Re-understanding relationship between intestinal flora and kidney disease from an ecological perspective[J].Chinese Journal of Nephrology,Dialysis & Transplantation,2020,29(2):176-180.(in Chinese)
[82] 吕锡斌,何腊平,张汝娇,等.双歧杆菌生理功能研究进展[J].食品工业科技,2013,34(16):353-358.LYU X B,HE L P,ZHANG R J,et al.Research progress in physiological functions of Bifidobacterium[J].Science and Technology of Food Industry,2013,34(16):353-358.(in Chinese)
[83] BASSETTI S,FREI R,ZIMMERLI W.Fungemia with Saccharomyces cerevisiae after treatment with Saccharomyces boulardii[J].American Journal of Medicine,1998,105(1):71-72.
[84] SALMINEN M K,TYNKKYNEN S,RAUTELIN H,et al.Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland[J].Clinical Infectious Diseases,2002,35(10):1155-1160.
[85] MACKAY A D,TAYLOR M B,KIBBLER C C,et al.Lactobacillus endocarditis caused by a probiotic organism[J].Clinical Microbiology and Infection,1999,5(5):290-292.
[86] MUNAKATA S,ARAKAWA C,KOHIRA R,et al.A case of D-lactic acid encephalopathy associated with use of probiotics[J].Brain & Development,2010,32(8):691-694.
[87] DRAKES M,BLANCHARD T,CZINN S.Bacterial probiotic modulation of dendritic cells[J].Infection and Immunity,2004,72(6):3299-3309.
[88] VAARALA O.Immunological effects of probiotics with special reference to Lactobacilli[J].Clinical and Experimental Allergy,2003,33(12):1634-1640.
[89] KLEIN G,HALLMANN C,CASAS I A,et al.Exclusion of vanA,vanB and vanC type glycopeptide resistance in strains of Lactobacillus reuteri and Lactobacillus rhamnosus used as probiotics by polymerase chain reaction and hybridization methods[J].Journal of Applied Microbiology,2000,89(5):815-824.
[90] 王响,刘峰,李思勉,等.功能性添加剂在宠物食品中的应用进展[J].饲料博览,2023,1:20-23.WANG X,LIU F,LI S M,et al.Application progress of functional additives in pet food[J].Feed Review,2023,1:20-23.(in Chinese)
[91] 袁华根,王锦锋,贺生中.非淀粉多糖酶制剂在犬粮中的应用前景[J].畜牧与饲料科学,2010,31(5):35-36.YUAN H G,WANG J F,HE S Z.Application prospects of non-starch polysaccharide enzyme in dog feed[J].Animal Husbandry and Feed Science,2010,31(5):35-36.(in Chinese)
[92] PIKE A L,HORWITZ D F,LOBPRISE H.An open-label prospective study of the use of L-theanine (anxitane) in storm-sensitive client-owned dogs[J].Journal of Veterinary Behavior Clinical Applications & Research,2015,10(4):324-331.
[93] 张鹏,王思源,李俞甫,等.植物性成分与犬肠道健康的研究进展[J].动物营养学报,2023,35(3):1361-1367.ZHANG P,WANG S Y,LI Y F,et al.Research progress of plant ingredients and canine intestinal health[J].Chinese Journal of Animal Nutrition,2023,35(3):1361-1367.(in Chinese)
[94] 汪倩,王建梅,安柯颖,等.增益素对溃疡性结肠炎犬免疫功能、肠道屏障和肠道菌群的影响[J].畜牧兽医学报,2023,54(3):1261-1272.WANG Q,WANG J M,AN K Y,et al.Effect of polyactin A on immune function,intestinal barrier and intestinal flora in dogs with ulcerative colitis[J].Acta Veterinaria et Zootechnica Sinica,2023,54(3):1261-1272.(in Chinese)
[95] 殷景远,单红艳.微生态制剂联合复方甘草酸苷治疗肝炎肝硬化的效果及对肠道菌群和血清炎性因子水平的影响[J].中国微生态学杂志,2024,36(7):803-807.YIN J Y,SHAN H Y.Effect of probiotics combined with compound glycyrrhizin glycoside for hepatitis B cirrhosis and its influences on gut microbiota and serum inflammatory factors[J].Chinese Journal of Microecology,2024,36(7):803-807.(in Chinese)
[96] 朱玉.色氨酸代谢及相关肠道菌群与脂肪性肝病关联的横断面研究[D].合肥:安徽医科大学,2023.ZHU Y.The association of tryptophan metabolism and related gut microbiota with fatty liver disease:A cross-sectional study[D].Hefei:Anhui Medical University,2023.(in Chinese)
[97] WIEGEL J.利用大数据监控动物健康和无抗生产[J].中国禽业导刊,2018,35(20):10.WIEGEL J.Utilizing big data for monitoring animal health and antibiotic-free production[J].Guide to Chinese Poultry,2018,35(20):10.(in Chinese)
[98] 梁峻阁,宋怡然,孙杨帆,等.基于可穿戴与可植入技术的人体健康物联网研究进展[J].物联网学报,2023,7(2):26-34.LIANG J G,SONG Y R,SUN Y F,et al.Research progress of human health IoT based on wearable and implantable techniques[J].Chinese Journal on Internet of Things,2023,7(2):26-34.(in Chinese)

Research Progress on the Effects of Functional Additives on Intestinal Health in Dogs

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	SHANG Kaiyuan, GUAN Jiuqiang, AN Tianwu, ZHAO Hongwen, BAI Qin, ZHANG Ming, WU Weisheng, LI Huade, SHA Quan, JIANG Mingfeng, ZHANG Xiangfei, LUO Xiaolin. Transcriptomics-based Analysis of the Mechanisms of Perinatal Nutritional Regulation on Nutrient Metabolism and Reproduction in Yak (Bos grunniens) [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3031-3046.
[2]	LI Duo, YUAN Xinxin, SHEN Zhehong, RUAN Fei, ZHAO Lulu, WANG Chuankun, ZENG Yaqi, YAO Xinkui, MENG Jun. Effects of Proline Supplementation on Growth Performance, Antioxidant and Immune Index and Cytokine Contents of Serum in Weaned Foals [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3084-3092.
[3]	LU Xinxin, FU Kaibo, LI Siman, ZHANG Haihua, ZHANG Haijun, QIU Kai, WU Shugeng. Effect of Dietary Malic Acid Supplemented in the Initial Growth Stage on Growth Performance, Meat Quality, Serum Biochemical and Intestinal Health of Broilers [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(7): 3104-3115.
[4]	ZHANG Bingyan, FAN Rui, FENG Shutang, JIA Junting, ZHANG Jianbin, MA Yuyuan. Whole Genome Resequencing Analysis of PERV Non-transmitting Zhong Xu Wuzhishan Mini-pig Inbred Line [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2459-2467.
[5]	WANG Haotian, LI Junzhe, MEI Xiaoying, LI Longxian, LI Yingying, ZHANG Mingrui, WU Yi. Effects of Cuscuta chinensis and Arctium lappa Compound Plant Extracts on Urine Physicochemical,Serum Antioxidant and Immune Indexes in Adult Cats [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2531-2539.
[6]	SUN Yuli, JIAO Ning, QU Yanghua, ZHANG Lei, ZHANG Xiaolin. Advance on the Feeding Value of Black Soldier Fly Larvae and Its Application in Pig Production [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2066-2077.
[7]	LIU Min, CHENG Huai, ZHENG Zhenzhen, ZHANG Mengsi, ZHANG Hewei, REN Jingqiang. Eukaryotic Expression and Polyclonal Antibody Preparation of N Protein of Canine Parainfluenza Virus [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2287-2294.
[8]	ZANG Xinyi, ZHANG Ruoyi, CHEN Zehan, FAN Shuyu, LI Jian. Effects of Qilan Compound on Immune Function,Reproductive Performance and Defecation Function of Perinatal Sows [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2341-2352.
[9]	WEI Ying, DUAN Yehui, DENG Jinping. Research Progress on the Application of Flavor Amino Acids in Pig and Chicken Production [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 1089-1101.
[10]	LIU Chengwu, SONG Mingqiang, ZHOU Shibing, ZHAO Jianli, WANG Wenxing. Differential Analysis of Gut Microbiota Composition Between Quiet and Lively Working Dogs [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 1131-1140.
[11]	WANG Zihua, YOU Wei, CHENG Haijian, HU Xin, HU Zhiyong, SONG Enliang, JIANG Fugui. Effects of Oleoresin Capsicum on Serum Biochemical,Immune and Antioxidant Indexes of Fattening Cattle [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 698-706.
[12]	ZHENG Jieqiu, XING Dongxu, LI Qingrong, LI Erna, FU Bing, LIAO Sentai, ZOU Yuxiao, ZHOU Donglai. Biological Functions of Rhodopseudomonas palustris and Its Research Progress in Aquaculture [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 707-717.
[13]	FENG Yi, YANG Yunyun, LUO Yongrong, WU Peng, WANG Yan, YANG Ying, CHEN Jiangfeng, JIANG Haibo, WEN Ming. Effect of Dietary Addition of Rosa roxburghii Tratt. Residue on Intestinal Histomorphology,Antioxidant Capacity,Immunity and Metabolomics in Common Carp (Cyprinus carpio) [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(1): 80-93.
[14]	XING Dongxu, FU Bing, WANG Junyan, LI Qingrong, ZHOU Donglai, YE Jinling, LIAO Sentai, RUAN Dong, ZOU Yuxiao. Effects of Dietary Fermented Mulberry Leaf Powder on Growth Performance, Antioxidant and Immune Capacity,and Gut Microbiota Structure of Yellow-feathered Broilers [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(1): 169-181.
[15]	WANG Lei, LIANG Lin, LUO Runqi, LIANG Ruiying, HU Dandan, SI Hongbin, DING Jiabo, DI Wenda, TANG Xinming. Research Advancement in Chicken Infectious Anemia Vaccine [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(1): 341-350.