兽用抗菌增效剂制剂的研究进展

doi:10.16431/j.cnki.1671-7236.2021.05.033

Abstract

Abstract: Antibacterial synergist is a kind of synthetic diaminopyrimidine drugs.When these drugs are used in combination with antibacterial agents,they will strengthen the activity of antibacterial agents through a specific mechanism.In recent years,the problem of bacterial resistance has become increasingly apparent due to the widespread use and even abuse of antibiotics.New preparations developed by adding antibacterial synergists can improve the utilization rate of antibiotics in animals,reduce drug dosage,enhance drug efficacy,reduce veterinary drug residues and reduce bacterial resistance.The preparation products prepared by the combination of TMP,DVD and ADP with various antibiotics were analyzed in recent years.It is found that the therapeutic effect of these preparations is generally better than those antibiotics alone.Besides,with the use of traditional Chinese medicine,the problem of bacterial resistance has been significantly improved,which opens a new prospect for the research direction of antibacterial synergist in the later study.With the research of veterinary drug preparation,it is no longer limited to simple dosage forms.Through the use of new technologies and new materials,the preparation developed can provide more accurate treatment for patients according to different drug delivery sites and routes,reduce the time for drugs to reach the target site,and increase the dosage of patients.This idea can provide support and reference for the follow-up research and development direction.In this paper,the research and development of the combination of antibiotics and antibacterial synergists are reviewed.

Key words: synergist for antibiotic drug; preparations; veterinary drug residues; drug resistance

CLC Number:

S859.5

LI Xin, WANG Zhixia, PAN Yuanhu, XIE Shuyu, YUAN Zonghui, HUANG Lingli, QU Wei. Progress Research on Antibacterial Synergist Preparation for Animals[J]. China Animal Husbandry & Veterinary Medicine, 2021, 48(5): 1816-1824.

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