钙振荡在哺乳动物卵母细胞受精过程中的作用

doi:10.16431/j.cnki.1671-7236.2021.04.021

Abstract

Abstract: Mammal sperm and oocytes are produced by meiosis,leading to haploid genomes.The gametes are highly specialized.After the sperm-oocytes fusion,the number of chromosomes are restored,and the developmental totipotency is re-obtained.Following that the mitosis is restarted and individual starts to grow.During fertilization,sperm causes the calcium ions (Ca²⁺) rising at a certain frequency,which is called Ca²⁺ oscillation.The Ca²⁺ oscillation drives the activity of downstream proteins to complete the activation of the oocytes.This article mainly discussed the mechanism of initiation,maintenance and function of Ca²⁺ oscillation during fertilization.The duration,amplitude,and frequency of Ca²⁺ oscillation affect the secretion of cortical granules,the resumption of MⅡ arrest,and the recruitment of maternal mRNA.This article also reviewed how Ca²⁺ oscillations activate maternal mRNA transcription and restart mitosis of zygote.Recent years,great progress has been achieved in discovering signaling pathways that drive oocytes activation events,but the molecular mechanisms involved in each individual event have not yet been fully determined.This review discussed the deficiencies and future directions of related reasarch.In the future,the elucidation of the role of Ca²⁺ oscillation will definitely benefit reproductive techniques for human and the livestock industry.

Key words: oocyte; fertilization; calcium oscillations; oocytes activation

CLC Number:

S814

ZHU Tianqi, LI Jia, LIU Guoshi, ZHANG Lu. The Roles of Calcium Oscillations in the Fertilization and Activation of Oocytes[J]. China Animal Husbandry & Veterinary Medicine, 2021, 48(4): 1343-1350.

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The Roles of Calcium Oscillations in the Fertilization and Activation of Oocytes

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