天然虾青素的生物学功能及其在动物生产中的应用

doi:10.16431/j.cnki.1671-7236.2019.10.019

Abstract

Abstract: Astaxanthin is a ketone carotenoid with many biological functions such as coloring,anti-oxidation,immunity enhancement and anti-cancer.Natural astaxanthin in poultry diet is digested,absorbed and transported by blood,liver and ovary, and eventually enriched in egg yolk to deepen yolk color.Meanwhile,due to its hydroxyl group and unsaturated ketone group,natural astaxanthin can effectively scavenge free radicals,increase the body's antioxidant enzyme activity,reduce the content of reactive oxygen and malondialdehyde,so as to reduce the oxidative stress damage.In addition,natural astaxanthin can improve the reproductive performance of animals by improving the semen quality and the secretion of reproductive hormones.Dietary natural astaxanthin not only brightens the skin color of aquatic animals,but also enhances immunity by participating in cellular and humoral immunity and inhibiting the inflammatory factor NF-κB signaling pathway.This paper briefly reviewed the structural characteristics,physicochemical properties,extraction and purification of astaxanthin,and its functions,such as coloring,anti-oxidation,improving immunity and anti-tumor were described in detail.In addition,the applications prospects of astaxanthin in livestock and aquaculture were analyzed aiming to lay a theoretical foundation for its further application in livestock production.

Key words: astaxanthin; biological function; application

CLC Number:

S816.7

GAO Shan, GUO Yong, CHEN Yu, QI Xiaolong. Biological Function of Natural Astaxanthin and Its Application in Animal Production[J]. China Animal Husbandry & Veterinary Medicine, 2019, 46(10): 2981-2987.

References

[1] HIGUERA-CIAPARA I,FELIX-VALENZUELA L,GOYCOOLEA F M.Astaxanthin:A review of its chemistry and applications[J].Food Science and Nutrition,2006,46(2):185-196.
[2] 张晓娜,惠伯棣,裴凌鹏,等.功能因子虾青素研究概况[J].中国食品添加剂,2017,162(8):208-214. ZHANG X N,HUI B L,PEI L P,et al.Research progress on functional factor of astaxanthin[J].China Food Additives,2017,162(8):208-214.(in Chinese)
[3] 彭永健,吕红萍,王胜南,等.天然虾青素的研究进展[J].中国食品添加剂,2017,158(4):193-197. PENG Y J,LYU H P,WANG S N,et al.Present research and prospect on natural astaxanthin[J].China Food Additives,2017,158(4):193-197.(in Chinese)
[4] 吴汝林,王丽红.加工处理对食品中类胡萝卜素顺反异构化作用的影响[J].食品科技,2006,11:126-129. WU R L,WANG L H.Effects of processing on trans-cis-isomerization of carotenoids in food[J].Food Science and Technology,2006,11:126-129.(in Chinese)
[5] CAPELLI B,BAGCHI D,CYSEWSKI G R.Synthetic astaxanthin is significantly inferior to algal-based astaxanthin as an antioxidant and may not be suitable as a human nutraceutical supplement[J].Nutrafoods,2013,12(4):145-152.
[6] WEERATUNGE W K,PERERA B G.Formulation of a fish feed for goldfish with natural astaxanthin extracted from shrimp waste[J].Chemistry Central Journal,2016,10(1):44-50.
[7] SARADA R,VIDHYAVATHI R,USHA D,et al.An efficient method for extraction of astaxanthin from green alga Haematococcus pluvialis[J].Journal of Agricultural and Food Chemistry,2006,54(20):7585-7588.
[8] KANG C D,SIM S J.Direct extraction of astaxanthin from Haematococcus culture using vegetable oils[J].Biotechnology Letters,2008,30(3):441-444.
[9] NADARA P.Ultrasound-assisted intensification of extraction of astaxanthin from Phaffia rhodozyma[Z].2015.
[10] ZOU T,JIA Q,LI H,et al.Response surface methodology for ultrasound-assisted extraction of astaxanthin from Haematococcus pluvialis[J].Marine Drugs,2013,11(5):1644-1655.
[11] REYES F A,MENDIOLA J A,IBAÑEZ E,et al.Astaxanthin extraction from Haematococcus pluvialis using CO₂-expanded ethanol[J].Journal of Supercritical Fluids,2014,92:75-83.
[12] 王钧艺,闫研,金辉东,等.虾青素复合添加剂对蛋鸡生产性能、蛋品质、蛋黄抗氧化指标和蛋黄中虾青素含量的影响[J].动物营养学报,2018,30(7):2700-2706. WANG J Y,YAN Y,JIN H D,et al.Effects of astaxanthin compound additive on performance,egg quality,yolk antioxidant indexes and yolk astaxanthin content of laying hens[J].Chinese Journal of Animal Nutrition,2017,30(7):2700-2706.(in Chinese)
[13] SONG X,WANG L,LI X,et al.Dietary astaxanthin improved the body pigmentation and antioxidant function,but not the growth of discus fish (Symphysodon spp.)[J].Aquaculture Research,2017,48(4):1359-1367.
[14] NAGUIB Y M.Antioxidant activities of astaxanthin and related carotenoids[J].Journal of Agricultural and Food Chemistry,2000,48(4):1150-1154.
[15] 刘科梅,邬子彬,胡基志,等.类胡萝卜素清除自由基活性构效关系[J].食品工业科技,2018,39(16):59-64. LIU K M,WU Z B,HU J Z,et al.The structure-activity relationship of free radical scavenging ability of carotenoids[J].Science and Technology of Food Industry,2018,39(16):59-64.(in Chinese)
[16] AUGUSTI P R.Astaxanthin prevents changes in the activities of thioredoxin reductase and paraoxonase in hypercholesterolemic rabbits[J].Journal of Clinical Biochemistry and Nutrition,2011,51(1):42-49.(in Chinese)
[17] 张珊珊,郑鑫,吴旻,等.虾青素对氧化应激小鼠肝原代细胞的保护作用[J].中国畜牧杂志,2018,54(4):98-102. ZHANG S S,ZHENG X,WU M,et al.Protective effect of astaxanthin on hepatic primary cells of oxidative stress mice[J].Chinese Journal of Animal Science,2018,54(4):98-102.(in Chinese)
[18] CHEN Q,TAO J,XIE X.Astaxanthin promotes Nrf2/ARE signaling to inhibit HG-induced renal fibrosis in GMCs[J].Marine Drugs,2018,16(4):117-133.
[19] 林谦,邱磊,云龙,等.核因子E2相关因子2调控机体抗氧化途径特性及其与畜禽的健康和肉品质的关系[J].动物营养学报,2014,26(6):1421-1429. LIN Q,QIU L,YUN L,et al.Nuclear factor erythroid-2-related factor 2 mediated antioxidant pathway character and its relation on health and meat quality of livestock and poultry[J].Chinese Journal of Animal Nutrition,2014,26(6):1421-1429.(in Chinese)
[20] NIU T,XUAN R,JIANG L,et al.Astaxanthin induces the Nrf2/HO-1 antioxidant pathway in human umbilical vein endothelial cells by generating trace amounts of ROS[J].Journal of Agricultural and Food Chemistry,2018,66(6):1551-1559.
[21] 海璇隽,凌雪萍,卢英华.虾青素对正常小鼠与衰老模型大鼠免疫指标的影响[J].厦门大学学报(自然科学版),2013,52(5):703-709. HAI X J,LING X P,LU Y H,et al.Effect of astaxanthin on immunological indexes of normal mice and aging model rats[J].Journal of Xiamen University (Natural Science),2013,52(5):703-709.(in Chinese)
[22] 刘颖芬,辛乃宏,李炳乾,等.雨生红球藻虾青素对小鼠免疫调节的研究[J].食品研究与开发,2017,38(20):183-187. LIU Y F,XIN N H,LI B Q,et al.Study of astaxanthin from Haematococcus pluvialis on immune regulation function in mice[J].Food Research and Development,2017,38(20):183-187.(in Chinese)
[23] PARK J S,MATHISON B D,HAYEK M G,et al.Astaxanthin stimulates cell-mediated and humoral immune responses in cats[J].Veterinary Immunology & Immunopathology,2011,144(3-4):455-461.
[24] KAMATH B S,SRIKANTA B M,DHARMESH S M,et al.Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis[J].European Journal of Pharmacology,2008,590(1-3):387-395.
[25] KANG H,KIM H.Astaxanthin and β-carotene in helicobacter pylori-induced gastric inflammation:A mini-review on action mechanisms[J].Journal of Cancer Prevention,2017,22(2):57-61.
[26] PARK J S,CHYUN J H,KIM Y K,et al.Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans[J].Nutrition & Metabolism,2010,7(1):18.
[27] WEN X,XIAO L,ZHONG Z,et al.Astaxanthin acts via LRP-1 to inhibit inflammation and reverse lipopolysaccharide-induced M1/M2 polarization of microglial cells[J].Oncotarget,2017,8(41):69370.
[28] NISHINO H,MURAKOSHI M,TOKUDA H,et al.Cancer prevention by carotenoids[J].Mutation Research,1998,483(2):165-168.
[29] YASUI Y,HOSOKAWA M,MIKAMI N,et al.Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines[J].Chemico-Biological Interactions,2011,193(1):79-87.
[30] ZHANG X,ZHAO W,HU L,et al.Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells[J].Archives of Biochemistry and Biophysics,2011,512(1):96-106.
[31] 张彩霞,江滨,张亚杰,等.间隙连接蛋白Cx43在肿瘤发生发展中的作用[J].辽宁中医药大学学报,2017,19(1):147-151. ZHANG C X,JIANG B,ZHANG Y J,et al.Role of connexin 43 in the genesis and development of tumor[J].Journal of Liaoning University of TCM,2017,19(1):147-151.(in Chinese)
[32] 彭光华,李忠,张声华.6种类胡萝卜素对人乳腺癌细胞株细胞间隙连接通讯功能影响的比较[J].食品科学,2008,29(6):45-48. PENG G H,LI Z,ZHANG S H.Comparison of effect of six kinds of carotenoids on gap junctional intercellular communication of human breast cancer cell[J].Food Science,2008,29(6):45-48.(in Chinese)
[33] VINE A L,LEUNG Y M,BERTRAM J S.Transcriptional regulation of connexin 43 expression by retinoids and carotenoids:Similarities and differences[J].Molecular Carcinogenesis,2005,43(2):75-85.
[34] SONG X D,ZHANG J J,WANG M R,et al.Astaxanthin induces mitochondria-mediated apoptosis in rat hepatocellular carcinoma CBRH-7919 cells[J].Biological & Pharmaceutical Bulletin,2011,34(6):839-844.
[35] KURIHARA H,KODA H,ASAMI S,et al.Contribution of the antioxidative property of astaxanthin to its protective effect on the promotion of cancer metastasis in mice treated with restraint stress[J].Life Sciences,2002,70(21):2509-2520.
[36] FRANCESCHELLI S,MIRKO P,ALESSIO F,et al.Astaxanthin treatment confers protection against oxidative stress in U937 cells stimulated with lipopolysaccharide reducing O₂^- production[J].2014,9(2):e88359.
[37] 付兴周,路志芳,李东.虾青素复合添加剂对肉鸡生长性能及肉质的影响[J].畜牧与兽医,2017,49(1):27-30. FU X Z,LU Z F,LI D.Effects of astaxanthin composite additives on growth performance and meat quality in the broiler[J].Animal Husbandry & Veterinary Medicine,2017,49(1):27-30.(in Chinese)
[38] 冯畅.虾青素对AA肉鸡血液理化指标和免疫功能的影响研究[D].长沙:湖南农业大学,2010. FENG C.Astaxanthin on effect of blood physiology biochemistry index and immune function of AA chicken[D].Changsha:Hunan Agricultural University,2010.(in Chinese)
[39] 李新杰,朱伟,姜威,等.天然虾青素对鸭肉品质和脂质氧化稳定性的影响[J].粮食与饲料工业,2012,6:43-45. LI X J,ZHU W,JIANG W,et al.Effects of natural astaxanthin on duck meat quality and lipid oxidative stability[J].Cereal and Feed Industry,2012,6:43-45.(in Chinese)
[40] 冯宇航,郭勇,陈余,等.复合酶制剂对产蛋鸡生产性能、蛋品质、氮磷及氨气排放的影响[J].北京农学院学报,2018,33(4):58-61. FENG Y H,GUO Y,CHEN Y,et al.Effects of compound enzyme preparation on production performance,egg quality,nitrogen and phosphorus and ammonia emission in laying hens[J].Journal of Beijing University of Agriculture,2018,33(4):58-61.(in Chinese)
[41] 王钧艺.日粮添加微藻DHA、虾青素复合添加剂、松针粉对蛋鸡生产性能及蛋品质影响[D].延吉:延边大学,2018. WANG J Y.Effect of dietary microalgae DHA,astaxanthin complex additives and pine needles on laying performance and egg quality of laying hens[D].Yanji:Yanbian University,2018.(in Chinese)
[42] 吴斯诺,臧素敏,郭欣,等.日粮添加虾青素对太行鸡生产性能和蛋品质的影响[J].中国家禽,2018,40(14):32-35. WU S N,ZANG S M,GUO X,et al.Effects of dietary astaxanthin on production performance and egg quality of Taihang chicken[J].China Poultry,2018,40(14):32-35.(in Chinese)
[43] 梁明振,梁贤威.着色剂问题探讨[J].粮食与饲料工业,2002,6:26-27. LIANG M Z,LIANG X W.A discussion on colorants[J].Cereal and Feed Industry,2002,6:26-27.(in Chinese)
[44] HIROKI I,SAKI S,HIRONORI T,et al.Effects of astaxanthin-rich dried cell powder from Paracoccus carotinifaciens on carotenoid composition and lipid peroxidation in skeletal muscle of broiler chickens under thermos-neutral or realistic high temperature conditions[J].Animal Science Journal,2019,90(2):229-236.
[45] SUN T,YIN R ,MAGNUSON A D,et al.Dietary supplemental microalgal astaxanthin produced dose-dependent enrichments and improved redox status in tissues of broiler chicks[J].Journal of Agricultural and Food Chemistry,2018,22:5521-5530.
[46] DO L T,LUU V V,MORITA Y,et al.Astaxanthin present in the maturation medium reduces negative effects of heat shock on the developmental competence of porcine oocytes[J].Reproductive Biology,2015,15(2):86-93.
[47] BASIOURA A,BOSCOS C M,PARRILLA I,et al.Effect of astaxanthin on the quality of boar sperm stored at 17℃,incubated at 37℃ or under in vitro conditions[J].Reproduction in Domestic Animals,2018,53(2):463-471.
[48] FANG Y,ZHONG R Z,CHEN L,et al.Effects of astaxanthin supplementation on the sperm quality and antioxidant capacity of ram semen during liquid storage[J].Small Ruminant Research,2015,130:178-182.
[49] KAMADA H,AKAGI S,WATANABE S.Astaxanthin increases progesterone production in cultured bovine luteal cells[J].Journal of Veterinary Medical Science,2017,79(6):1103-1109.
[50] BOWEN J,SOUTAR C,SERWATA R D,et al.Utilization of (3S,3￠S)-astaxanthin acyl esters in pigmentation of rainbow trout (Oncorhynchus mykiss)[J].Aquaculture Nutrition,2002,8(1):59-68.
[51] 韩星星,王秋荣,叶坤,等.叶黄素和虾青素对大黄鱼体色及抗氧化能力的影响[J].渔业研究,2018,40(2):104-110. HAN X X,WANG Q R,YE K,et al.Effect of xanthophylls and astaxanthin on the skin color and antioxidant capacity of Large yellow croaker (Larimichthys crocea)[J].Journal of Fisheries Research,2018,40(2):104-110.(in Chinese)
[52] WANG H,DAI A,LIU F,et al.Effects of dietary astaxanthin on the immune response,resistance to white spot syndrome virus and transcription of antioxidant enzyme genes in pacific White shrimp Litopenaeus vannamei[J].Iranian Journal of Fisheries Sciences,2015,14(3):699-718.
[53] CHENG C H,GUO Z X,YE C X,et al.Effect of dietary astaxanthin on the growth performance,non-specific immunity,and antioxidant capacity of pufferfish (Takifugu obscurus) under high temperature stress[J].Fish Physiology and Biochemistry,2018,44(1):209-218.

Biological Function of Natural Astaxanthin and Its Application in Animal Production

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	ZHANG Yuying, XING Jiabao, ZHANG Yichao, ZHANG Hang, ZHANG Junkai, ZHAI Yajun, ZHAO Jinxin, WU Hua. Research Progress on Phage Against Klebsiella pneumoniae Infection and Clinical Application [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(6): 2955-2964.
[2]	TANG Huangyao, ZHANG Wei, WEI Hao, WANG Feiying, LIAO Xiaocui, ZHANG Zhenyu. Research Progress on Biological Functions of Soy Isoflavones and Its Application in Animal Production [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2157-2165.
[3]	YUAN Qing, MENG Ru, LI Guoping, ZHANG Rui. Advances in Application of CRISPR-Cas Technology in the Detection of Animal Pathogenic Microorganisms [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(2): 545-553.
[4]	YAN Tingting, ZHAO Jingwen, ZHAO Shengguo, WU Huiguang. Advance in Bacteriophage-derived Antibacterial Proteins and Their Synergistic Mechanisms [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(1): 322-330.
[5]	PENG Ying, XIANG Yifei, YI Dandan, LIU Xia, WANG Menghui, ZHAO Linyi, HE Jiakang. Advances in Biological Functions of Rosmarinic Acid and Its Application in Animal Production [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(5): 1912-1920.
[6]	CAI Cimei, MA Chong, ZHU Jianfeng, PANG Xu, QI Jiaojiao, LI Xueling, YANG Meiyan, HU Wenfeng, HU Bin. Advance of Applications of Hermetia illucens L.Larvae as Feedstock in Pig Production [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(4): 1500-1510.
[7]	PENG Cong, LI Jing, TANG Xiaopeng, WANG Zixuan, WU Yuhong, ZHU Yiping. Research Progress on the Application of Platelet-rich Plasma in the Equine Locomotor System Injuries [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(4): 1784-1791.
[8]	JIANG Huiqiong, LIU Yating, CHEN Qinghua. Physiological Function of Superoxide Dismutase and Its Application Prospect in Animal Production [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(3): 945-954.
[9]	WANG Xiaofang, WANG Yawen, LI Jiefeng, FU Le, ZHANG Ning, QIN Jianhua. Screening and Application Research of Traditional Chinese Medicine Formulas for Anti-heat Stress in Dairy Cows [J]. China Animal Husbandry & Veterinary Medicine, 2024, 51(11): 5064-5073.
[10]	DENG Xinyi, HUANG Jiahuan, ZHAO Chengming, MA Wenao, GE Ye, CHEN Zhibao. Effect of Astaxanthin on Immune Function in Immunosuppressed Mice [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(9): 3519-3529.
[11]	WANG Manxi, LI Qinghao, SUN Juan, HU Hui, JIN Xin. Culture Methods and Application Prospects of Organoids [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(7): 2688-2696.
[12]	WU Xuan, ZENG Shenming. Research Progress on the Function,Application and Purification Technology in Serum Albumin [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(6): 2265-2275.
[13]	LIU Bin, LI Meng, XI Qianyun, SUN Jiajie, LUO Junyi, ZHANG Yongliang, CHEN Ting. Research Progress on Biological Characteristics of Hermetia illucens L. and Its Application in Poultry Production [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(2): 586-597.
[14]	ZHAO Lei, WANG Yi, LIU Yunzhuo, XU Wanxin, WANG Guiqin, LI Muyang. Effects of Astaxanthin on the Expression of Antioxidation, Inflammation and Glucocorticoid Receptor Protein in Liver of Channa argus Induced by Lipopolysaccharide [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(11): 4776-4782.
[15]	CHEN Jun, CAI Haiming, LIAO Shenquan, QI Nanshan, LI Juan, LYU Minna, LIN Xuhui, HU Junjing, ZHANG Jianfei, LIU Wenjun, SUN Mingfei. Review on the Research of DNA Helicase Family in Parasitic Protozoa [J]. China Animal Husbandry & Veterinary Medicine, 2023, 50(1): 317-327.