Abstract: The experiment by the way of constant-release melatonin two years and abstract skin total RNA Real-time PCR to Inner Mongolia Cashmere goats, for depth study melatonin effects on SOX21 gene. Used GAPDH gene as housekeeping gene to correct the quantitative data relative which obtain by Real-time PCR,the data by 2-△△Ct analysis found that: ① SOX21 gene in different individuals expressions in the trend was relative stability and variability impact of hormones. ② There were significant effect in addition to March,April,May in the SOX21 gene expression was no trend significant change,the other months had changed significantly. ③ While constant-release melatonin on the SOX21 gene expression,reducing the goat of the stress response to melatonin. ④The SOX21 gene express was down regulation in the hair follicle telogen.

Key words: Cashmere goats; constant-release; Real-time PCR; melatonin; SOX21 gene