马运动代谢组及其相关通路研究进展

doi:10.16431/j.cnki.1671-7236.2025.11.004

摘要/Abstract

摘要： 随着马产业的不断发展，对马运动能力的研究日益受到关注。代谢组学技术作为一种新兴的研究手段，为深入了解马在运动过程中的代谢变化提供了新的视角。代谢组学技术主要包括核磁共振(NMR)、气相色谱-质谱法(GC-MS)、液相色谱-质谱法(LC-MS)等，已广泛应用于马运动相关研究，涵盖了运动性状、运动生理、运动相关疾病等多个方面，研究内容主要包括对马速度、耐力运动中能量代谢的动态适应机制的解析；训练提升马运动性能的代谢组机理的分析；马运动疾病特征代谢物、诊疗靶点的鉴定；营养干预和抗氧化策略对马运动能力和机体恢复的代谢组机制的探究。笔者系统介绍了代谢组学的基本概念与研究方法，重点梳理了马运动相关代谢组学的研究成果，同时解析了与马运动密切相关的糖类、蛋白质和氨基酸、脂类等代谢通路及其运动中的动态适应机制。代谢组学与多组学的整合有望为马运动相关研究带来重大突破。

关键词: 马; 运动; 代谢组学; 代谢通路

Abstract: With the continuous development of the equine industry,the research on the athletic capabilities of horses has increasingly drawn attention.As an emerging research methodology,metabolomics technologies offer a novel tool for in-depth exploration of the metabolic alterations in horses during exercise.The metabolomics technologies mainly encompass nuclear magnetic resonance (NMR),gas chromatography-mass spectrometry (GC-MS),liquid chromatography-mass spectrometry (LC-MS),etc.,which have been extensively applied in horse sports-related research,covering multiple fields such as sports traits,exercise physiology,and sports-related diseases,which include revealing the dynamic adaptation mechanism of energy metabolism in sports types such as horse speed and endurance,studying the metabolic mechanism of improving the exercise performance of horses through training,identifying the characteristic metabolites of horse sports diseases and providing targets for diagnosis and treatment,and exploring the metabolic mechanism of nutritional intervention and antioxidant strategies on the exercise capacity and body recovery of horses.In the review,the authors systematically introduce the basic concepts and research methods of metabolomics,and focuse on the research results of horse exercise-related metabolomics.At the same time,the metabolic pathways of carbohydrates,proteins and amino acids,and lipids closely related to horse exercise,as well as their dynamic adaptive mechanisms during exercise are summarized.The integration of metabolomics and multi-omics is expected to lead to significant breakthroughs in horse sports-related research.

Key words: horse; exercise; metabolomics; metabolic pathway

中图分类号:

S821

钱诗雨, 姚茹玉, 张鹤潼, 邢雯慧, 伍家辉, 李媛媛, 赵春江. 马运动代谢组及其相关通路研究进展[J]. 中国畜牧兽医, 2025, 52(11): 5053-5062.

QIAN Shiyu, YAO Ruyu, ZHANG Hetong, XING Wenhui, WU Jiahui, LI Yuanyuan, ZHAO Chunjiang. Advances in Equine Exercise Metabolome and Its Associated Metabolic Pathways[J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(11): 5053-5062.

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